Herndon Leon W, Weizer Jennifer S, Stinnett Sandra S
Duke University Eye Center, Durham, NC 27710, USA.
Arch Ophthalmol. 2004 Jan;122(1):17-21. doi: 10.1001/archopht.122.1.17.
To determine if central corneal thickness (CCT) is related to the level of glaucoma severity at the initial examination.
The initial visit to a glaucoma specialist by consecutive patients with primary open-angle glaucoma from 1997 to 2002 was reviewed retrospectively. Each patient's age, sex, race, family history of glaucoma, number of glaucoma medications, visual acuity, spherical equivalent, intraocular pressure, CCT, visual field data, and vertical and horizontal cup-disc ratios were analyzed.
Three hundred fifty eyes of 190 patients met the inclusion and exclusion criteria. Central corneal thickness was significantly lower in blacks (mean, 537 microm) than in whites (mean, 556 microm). Lower CCT was significantly associated with worsened Advanced Glaucoma Intervention Study score, worsened mean deviation of visual field, increased vertical and horizontal cup-disc ratios, and increased number of glaucoma medications. In multivariate analysis, lower CCT was significantly associated with worsened Advanced Glaucoma Intervention Study score, worsened mean deviation of visual field, and increased vertical and horizontal cup-disc ratios.
Central corneal thickness is a powerful clinical factor in determining glaucoma severity at the initial examination by a specialist. Measuring CCT may aid the ophthalmologist in identification of glaucoma patients at high risk for progression.
确定初次检查时中央角膜厚度（CCT）是否与青光眼严重程度相关。
回顾性分析1997年至2002年连续就诊于青光眼专科医生的原发性开角型青光眼患者的初次就诊情况。分析每位患者的年龄、性别、种族、青光眼家族史、青光眼药物数量、视力、等效球镜度、眼压、CCT、视野数据以及垂直和水平杯盘比。
190例患者的350只眼符合纳入和排除标准。黑人的中央角膜厚度（平均537微米）显著低于白人（平均556微米）。较低的CCT与较差的青光眼干预研究（Advanced Glaucoma Intervention Study）评分、较差的视野平均偏差、增加的垂直和水平杯盘比以及增加的青光眼药物数量显著相关。在多变量分析中，较低的CCT与较差的青光眼干预研究评分、较差的视野平均偏差以及增加的垂直和水平杯盘比显著相关。
中央角膜厚度是专科医生初次检查时确定青光眼严重程度的一个重要临床因素。测量CCT可能有助于眼科医生识别有进展高风险的青光眼患者。
