Koop H, Bachem M G
Department of Medicine, Philipps-University, Marburg, Germany.
J Clin Gastroenterol. 1992 Jun;14(4):288-92. doi: 10.1097/00004836-199206000-00005.
Since gastric acid plays an important role in the absorption process of iron and vitamin B12, we determined levels of iron, ferritin, vitamin B12, and folic acid in 75 serum samples obtained during continuous omeprazole therapy (6-48 months after start of therapy) from 34 patients with peptic diseases (primarily reflux esophagitis). Serum iron and ferritin levels were decreased in two and three patients, respectively, but there is little evidence that omeprazole administration was causally related to these findings. Serum vitamin B12 and folic acid levels were normal in all cases. We conclude that iron, vitamin B12, and folic acid malabsorption is unlikely to occur, at least within the initial 3-4 years of continuous omeprazole therapy.
由于胃酸在铁和维生素B12的吸收过程中起重要作用，我们测定了34例消化性疾病（主要是反流性食管炎）患者在连续使用奥美拉唑治疗期间（治疗开始后6 - 48个月）采集的75份血清样本中的铁、铁蛋白、维生素B12和叶酸水平。分别有2例和3例患者的血清铁和铁蛋白水平降低，但几乎没有证据表明使用奥美拉唑与这些结果存在因果关系。所有病例的血清维生素B12和叶酸水平均正常。我们得出结论，至少在连续使用奥美拉唑治疗的最初3 - 4年内，不太可能发生铁、维生素B12和叶酸吸收不良的情况。
