Westerterp-Plantenga Margriet S, Lejeune Manuela P G M, Kovacs Eva M R
Department of Human Biology, Maastricht University, PO Box 616, NL-6200 MD Maastricht, The Netherlands.
Obes Res. 2005 Jul;13(7):1195-204. doi: 10.1038/oby.2005.142.
Investigation of the effect of a green tea-caffeine mixture on weight maintenance after body weight loss in moderately obese subjects in relation to habitual caffeine intake.
A randomized placebo-controlled double blind parallel trial in 76 overweight and moderately obese subjects, (BMI, 27.5 +/- 2.7 kg/m2) matched for sex, age, BMI, height, body mass, and habitual caffeine intake was conducted. A very low energy diet intervention during 4 weeks was followed by 3 months of weight maintenance (WM); during the WM period, the subjects received a green tea-caffeine mixture (270 mg epigallocatechin gallate + 150 mg caffeine per day) or placebo.
Subjects lost 5.9 +/-1.8 (SD) kg (7.0 +/- 2.1%) of body weight (p < 0.001). At baseline, satiety was positively, and in women, leptin was inversely, related to subjects' habitual caffeine consumption (p < 0.01). High caffeine consumers reduced weight, fat mass, and waist circumference more than low caffeine consumers; resting energy expenditure was reduced less and respiratory quotient was reduced more during weight loss (p < 0.01). In the low caffeine consumers, during WM, green tea still reduced body weight, waist, respiratory quotient and body fat, whereas resting energy expenditure was increased compared with a restoration of these variables with placebo (p < 0.01). In the high caffeine consumers, no effects of the green tea-caffeine mixture were observed during WM.
High caffeine intake was associated with weight loss through thermogenesis and fat oxidation and with suppressed leptin in women. In habitual low caffeine consumers, the green tea-caffeine mixture improved WM, partly through thermogenesis and fat oxidation.
研究绿茶 - 咖啡因混合物对中度肥胖受试者体重减轻后体重维持的影响，并探讨其与习惯性咖啡因摄入量的关系。
对76名超重和中度肥胖受试者（BMI为27.5±2.7kg/m²）进行了一项随机、安慰剂对照、双盲平行试验，这些受试者在性别、年龄、BMI、身高、体重和习惯性咖啡因摄入量方面相匹配。先进行为期4周的极低能量饮食干预，随后是3个月的体重维持期（WM）；在WM期间，受试者接受绿茶 - 咖啡因混合物（每天270毫克表没食子儿茶素没食子酸酯 + 150毫克咖啡因）或安慰剂。
受试者体重减轻了5.9±1.8（标准差）千克（7.0±2.1%）（p<0.001）。在基线时，饱腹感与受试者的习惯性咖啡因摄入量呈正相关，而在女性中，瘦素与习惯性咖啡因摄入量呈负相关（p<0.01）。高咖啡因消费者比低咖啡因消费者体重、脂肪量和腰围减少得更多；在体重减轻期间，静息能量消耗减少较少，呼吸商减少较多（p<0.01）。在低咖啡因消费者中，在WM期间，绿茶仍能减轻体重、腰围、呼吸商和体脂，而与安慰剂使这些变量恢复相比，静息能量消耗增加（p<0.01）。在高咖啡因消费者中，在WM期间未观察到绿茶 - 咖啡因混合物的效果。
高咖啡因摄入量与通过产热和脂肪氧化导致的体重减轻以及女性瘦素抑制有关。在习惯性低咖啡因消费者中，绿茶 - 咖啡因混合物部分通过产热和脂肪氧化改善了体重维持。
