Singh Ravinder, Valcárcel Juan
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA.
Nat Struct Mol Biol. 2005 Aug;12(8):645-53. doi: 10.1038/nsmb961.
Specificity is key to biological regulation. Two families of RNA binding proteins, heterogeneous nuclear ribonucleoproteins and serine-arginine-rich proteins, were initially thought to have redundant or nonspecific biochemical functions. Recently, members of these families have been found as components of distinct regulatory complexes with highly specific and essential roles in mRNA metabolism. Here we discuss the basis for their functional specificity and the mechanisms of action of some of their characteristic protein domains.
特异性是生物调节的关键。RNA结合蛋白的两个家族，即不均一核核糖核蛋白和富含丝氨酸-精氨酸的蛋白，最初被认为具有冗余或非特异性的生化功能。最近，这些家族的成员已被发现是不同调节复合物的组成部分，在mRNA代谢中具有高度特异性和重要作用。在这里，我们讨论了它们功能特异性的基础以及它们一些特征性蛋白结构域的作用机制。
