Champy Pierre, Melot Alice, Guérineau Eng Vincent, Gleye Christophe, Fall Djibril, Höglinger Gunter U, Ruberg Merle, Lannuzel Annie, Laprévote Olivier, Laurens Alain, Hocquemiller Reynald
Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique BioCIS, Faculté de Pharmacie Paris XI, Châtenay-Malabry, France.
Mov Disord. 2005 Dec;20(12):1629-33. doi: 10.1002/mds.20632.
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 microg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion.
瓜德罗普岛的非典型帕金森病与食用番荔枝科的刺果番荔枝（Annona muricata L.）的果实以及用其叶子制成的浸剂或煎剂有关，刺果番荔枝含有番荔枝乙酰精，这是一种线粒体呼吸链复合体I的亲脂性抑制剂。我们通过基质辅助激光解吸电离质谱法测定了刺果番荔枝果实和叶子提取物中主要乙酰精annonacin的浓度。据估计，一个刺果番荔枝果实平均含有约15毫克annonacin，一罐市售花蜜含有36毫克，一杯浸剂或煎剂含有140微克。作为其潜在毒性的一个指标，估计一名每天食用一个果实或一罐花蜜的成年人在一年时间内摄入的annonacin量，相当于通过静脉输注接受纯化annonacin的大鼠诱发脑损伤的量。
