Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/República Saharaui, 7, Puerto Real, 11510 Cadiz, Spain.
Molecules. 2021 May 14;26(10):2926. doi: 10.3390/molecules26102926.
Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from Mill.
木鳖果，又名“刺角瓜”，是隶属于番荔枝科的一个物种，在传统医学中被广泛应用，并且已被证实是生物活性化合物的宝贵来源。该科独有的一类次生代谢物为番荔枝烷型乙酰辅酶 A 水解酶，是一种脂溶性多酮类化合物，被认为是最有效的抗肿瘤化合物之一。本综述概述了木鳖果中乙酰辅酶 A 水解酶的化学多样性、分离程序、生物活性、应用模式和合成衍生物。
