Takser Larissa, Mergler Donna, Baldwin Mary, de Grosbois Sylvie, Smargiassi Audrey, Lafond Julie
Laboratoire de Physiologie Materno-foetale, Université du Quebec à Montréal, Montréal, Quebec, Canada.
Environ Health Perspect. 2005 Aug;113(8):1039-45. doi: 10.1289/ehp.7685.
Polychlorinated biphenyls (PCBs), chlorinated pesticides, and mercury are global environmental contaminants that can disrupt the endocrine system in animals and humans. However, there is little evidence that they can interfere with endocrine status in pregnant women and neonates at low levels of exposure. The aim of this study was to examine thyroid hormone levels during pregnancy and in cord blood in relation to blood concentrations of organochlorine compounds (OCs) and Hg in healthy women recruited during pregnancy. We found a significant negative correlation between maternal total triiodothyronine levels and three non-coplanar congeners (PCB-138, PCB-153, and PCB-180), three pesticides (p,p -DDE, cis-nanochlor, and hexachlorobenzene), and inorganic Hg independently, without any other changes in thyroid status. No significant relationships were observed between OCs and cord serum thyroid hormones. Cord serum free thyroxin was negatively correlated with inorganic Hg. These results suggest that at even low levels of exposure, persistent environmental contaminants can interfere with thyroid status during pregnancy.
多氯联苯（PCBs）、氯化农药和汞是全球性环境污染物，可扰乱动物和人类的内分泌系统。然而，几乎没有证据表明它们在低暴露水平下会干扰孕妇和新生儿的内分泌状态。本研究的目的是检测孕期健康女性及其脐带血中的甲状腺激素水平，并分析其与有机氯化合物（OCs）和汞血浓度之间的关系。我们发现，孕妇血清总三碘甲状腺原氨酸水平与三种非共面多氯联苯同系物（PCB - 138、PCB - 153和PCB - 180）、三种农药（p,p - DDE、顺式氯丹和六氯苯）以及无机汞之间存在显著负相关，且甲状腺状态无其他变化。未观察到OCs与脐带血清甲状腺激素之间存在显著关系。脐带血清游离甲状腺素与无机汞呈负相关。这些结果表明，即使在低暴露水平下，持久性环境污染物也会干扰孕期甲状腺状态。
