Li Chengcheng, Cheng Yibin, Tang Quan, Lin Shaobin, Li Yonghong, Hu Xiaojian, Nian Juan, Gu Heng, Lu Yifu, Tang Hong, Dai Shougui, Zhang Hongqun, Jin Cong, Zhang Haijing, Jin Yuanyuan, Jin Yinlong
Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
Yancheng Municipal Center for Disease Control and Prevention, Yancheng 224002, Jiangsu, China.
Environ Res. 2014 Feb;129:47-51. doi: 10.1016/j.envres.2013.12.009. Epub 2014 Jan 15.
Organochlorine pesticides can interfere with the thyroid hormones that play an important role in early neurodevelopment. Although organochlorine pesticides have been banned in China since 1983, their residues are still detectable in the environment. However, few studies have investigated the adverse health effects of prenatal exposure to organochlorine pesticide residues on newborns in China. The present study, conducted in Yancheng City, Jiangsu Province, China, aimed to examine the association between the levels of organochlorine pesticides in maternal and cord sera and to assess the impact of prenatal exposure to organochlorine pesticides on thyroid hormone levels in cord serum. Eleven organochlorine pesticides in maternal and cord sera were measured in 247 mother-infant pairs recruited from Yancheng City between February 2010 and June 2010. The concentration of the thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) were determined in cord serum. Among the 11 tested organochlorine pesticides, the detectable levels of hexachlorobenzene (HCB), β-hexachlorocycolohexane (β-HCH) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in both maternal and cord sera were above 50%. The levels of β-HCH and p,p'-DDE in maternal sera were positively associated with the levels in cord sera (r=0.421, P<0.01; r=0.288, P<0.01). After adjusting for confounders, the TSH level in cord serum samples was negatively associated with the HCB level (OR=0.535, 95% CI=(0.304-0.941)). Our data demonstrated that DDT, β-HCH and HCB residues bioconcentrate in maternal and cord sera. Moreover, the correlation analysis suggested that organochlorine pesticides in maternal blood can transfer through the placenta and affect newborn thyroid hormone levels.
有机氯农药会干扰在早期神经发育中起重要作用的甲状腺激素。尽管自1983年起中国已禁止使用有机氯农药，但在环境中仍可检测到其残留。然而，在中国，很少有研究调查产前接触有机氯农药残留对新生儿健康的不良影响。本研究在中国江苏省盐城市开展，旨在检验母血和脐血中有机氯农药水平之间的关联，并评估产前接触有机氯农药对脐血中甲状腺激素水平的影响。在2010年2月至2010年6月期间，对从盐城市招募的247对母婴进行了母血和脐血中11种有机氯农药的检测。测定了脐血中游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和促甲状腺激素（TSH）的浓度。在检测的11种有机氯农药中，母血和脐血中六氯苯（HCB）、β-六氯环己烷（β-HCH）和p,p'-二氯二苯二氯乙烯（p,p'-DDE）的可检测水平均超过50%。母血中β-HCH和p,p'-DDE的水平与脐血中的水平呈正相关（r=0.421，P<0.01；r=0.288，P<0.01）。在对混杂因素进行校正后，脐血样本中的TSH水平与HCB水平呈负相关（OR=0.535，95%CI=（0.304 - 0.941））。我们的数据表明，滴滴涕、β-HCH和HCB残留会在母血和脐血中生物富集。此外，相关性分析表明，母血中的有机氯农药可通过胎盘转移并影响新生儿甲状腺激素水平。
