Department of Clinical Sciences Malmo, Lund University, Skane University Hospital, 205 02 Malmö, Sweden.
Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
Medicina (Kaunas). 2022 Mar 2;58(3):373. doi: 10.3390/medicina58030373.
: Early vascular aging determines a more rapid course of age-related arterial changes. It may be induced by a proinflammatory state, caused by hyperuricemia and metabolic syndrome and their interrelationship. However, the impact of serum uric acid (SUA) on early arterial stiffening and vascular function remains uncertain. : A total of 696 participants (439 women aged 50-65 and 257 men aged 40-55) from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program were enrolled in the study. They underwent anthropometric measurements and laboratory testing along with arterial parameters' evaluation. Quality carotid stiffness (QCS), carotid-radial pulse wave velocity (crPWV), carotid-femoral pulse wave velocity (cfPWV), flow-mediated dilatation (FMD), and carotid intima-media thickness (CIMT) were registered. : We found that hyperuricemia was significantly associated with inflammation, registered by high-sensitivity C-reactive protein in both sexes. A very weak but significant association was observed between cfPWV and SUA in men and in women, while, after adjusting for risk factors, it remained significant only in women. A positive, weak, but significant association was also observed for QCS, both right and left in women. No relationship was observed between crPWV, FMD, CIMT, and SUA.
早期血管衰老决定了与年龄相关的动脉变化的更快进程。它可能是由高尿酸血症和代谢综合征及其相互关系引起的促炎状态引起的。然而，血清尿酸（SUA）对早期动脉僵硬和血管功能的影响仍不确定。
共有 696 名来自立陶宛高心血管风险（LitHiR）初级预防计划的参与者（439 名年龄在 50-65 岁的女性和 257 名年龄在 40-55 岁的男性）参与了这项研究。他们接受了人体测量和实验室测试以及动脉参数评估。记录了质量颈动脉僵硬（QCS）、颈动脉-桡动脉脉搏波速度（crPWV）、颈动脉-股动脉脉搏波速度（cfPWV）、血流介导的扩张（FMD）和颈动脉内膜中层厚度（CIMT）。
我们发现，高尿酸血症与两种性别中的高敏 C 反应蛋白所记录的炎症显著相关。在男性和女性中，cfPWV 与 SUA 之间存在非常弱但显著的关联，而在调整了危险因素后，这种关联在女性中仍然显著。在女性中，QCS 也存在阳性、微弱但显著的关联，无论是右侧还是左侧。crPWV、FMD、CIMT 和 SUA 之间没有关系。
