Neu Josef, Chen Mike, Beierle Elizabeth
Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32608, USA.
Semin Pediatr Surg. 2005 Aug;14(3):137-44. doi: 10.1053/j.sempedsurg.2005.05.001.
The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood, but appears to be multifactorial and highly associated with immaturity of the gastrointestinal tract, colonization of the intestinal microbiota, and immature innate immune system. The goal of this review is to provide an overview of some of these risk factors and how they might lead to the genesis of NEC. A better understanding of these factors should help us prevent and treat this devastating disease.
坏死性小肠结肠炎（NEC）的发病机制尚不清楚，但似乎是多因素的，并且与胃肠道不成熟、肠道微生物群定植以及先天免疫系统不成熟高度相关。本综述的目的是概述其中一些风险因素以及它们如何可能导致NEC的发生。更好地理解这些因素应有助于我们预防和治疗这种毁灭性疾病。
