Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1666-70. doi: 10.1167/iovs.09-4375. Epub 2009 Nov 11.
To analyze the preoperative results of multifocal electroretinography (mfERG) in the fellow eyes of patients with idiopathic unilateral macular hole and to evaluate the usefulness of this method in predicting the likelihood of macular hole formation in the fellow eye.
Over a period of 5 years, 80 eyes of 40 patients (mean age, 64.9 years) with unilateral idiopathic macular hole were examined. The diagnosis of idiopathic macular hole was confirmed by optical coherence tomography (OCT). The fellow eyes were intact in all cases. All patients underwent vitreoretinal surgery. Before the surgery, both eyes of the patients were examined by mfERG. During the follow-up period, the 40 fellow eyes were also observed by OCT, and the changes in the vitreofoveal attachment were investigated. The preoperative response densities and ring ratios of mfERG were analyzed in both eyes, and discriminant analysis was used to calculate the best separator function.
Preoperative mfERGs demonstrated significantly lower mean response densities in the central area of the 40 eyes with macular hole than in the fellow eyes. During the follow-up period, macular hole was diagnosed in 13 fellow eyes by OCT. The preoperative values of the mfERGs in these eyes were significantly lower than in the other 27 cases. The mfERG ring ratios were significantly lower in the fellow eyes in which macular holes developed than in those that remained intact.
The analysis of ERG in the fellow eyes of patients with macular hole seems clinically useful. The lower amplitude may forecast the propensity for subsequent development of a macular hole. Patients with low central ERG amplitude and lower ring ratios in the healthy fellow eyes should have stricter follow-up.
分析特发性单侧黄斑裂孔患者对侧眼的多焦视网膜电图（mfERG）术前结果，评估该方法在预测对侧眼黄斑裂孔形成可能性方面的作用。
在 5 年的时间里，对 40 例（平均年龄 64.9 岁）单侧特发性黄斑裂孔患者的 80 只眼进行了检查。通过光学相干断层扫描（OCT）确诊为特发性黄斑裂孔。所有病例对侧眼均完整。所有患者均接受了玻璃体视网膜手术。手术前，所有患者的双眼均接受 mfERG 检查。在随访期间，通过 OCT 观察 40 只对侧眼，并研究玻璃体黄斑粘连的变化。对双眼术前 mfERG 的反应密度和环比进行分析，使用判别分析计算最佳分离函数。
术前 mfERG 显示 40 只黄斑裂孔眼中中央区的平均反应密度明显低于对侧眼。在随访期间，通过 OCT 在 13 只对侧眼中诊断出黄斑裂孔。这些眼的 mfERG 术前值明显低于其他 27 例。发生黄斑裂孔的对侧眼的 mfERG 环比明显低于保持完整的对侧眼。
分析黄斑裂孔患者对侧眼的 ERG 似乎具有临床意义。振幅降低可能预示着随后发生黄斑裂孔的倾向。具有低中央 ERG 振幅和健康对侧眼低环比的患者应进行更严格的随访。
