Whitaker D, Henderson D W, Shilkin K B
Department of Histopathology, Sir Charles Gairdner Hospital, Perth, Australia.
Semin Diagn Pathol. 1992 May;9(2):151-61.
The concept of mesothelioma in situ is explored by a detailed examination of seven patients, subsequently proven to have pleural malignant mesothelioma, who initially had no evidence of gross tumor and for whom biopsy material was available at this early presentation. The tissue was assessed by routine microscopy, the immunoperoxidase technique for epithelial membrane antigen and silver staining for nucleolar organizer regions. Tiny lesions of the pleura that merged with or were adjacent to microscopically flat monolayered or folded mesothelium with cytological atypia were observed. The atypical cells reacted positively to epithelial membrane antigen, and the nucleolar organizer region counts were elevated. These observations are considered to support the possibility of the presence of mesothelioma in situ. These findings are discussed in the light of the proposed concept of mesothelioma in situ, its histogenesis, and its possible clinical relevance.
通过对七名患者的详细检查探讨了原位间皮瘤的概念。这七名患者随后被证实患有胸膜恶性间皮瘤，他们最初没有肉眼可见肿瘤的证据，并且在疾病早期就有活检材料。通过常规显微镜检查、上皮膜抗原免疫过氧化物酶技术和核仁组织区银染对组织进行评估。观察到胸膜的微小病变与显微镜下扁平单层或折叠的间皮合并或相邻，伴有细胞异型性。非典型细胞对上皮膜抗原呈阳性反应，核仁组织区计数升高。这些观察结果被认为支持原位间皮瘤存在的可能性。根据原位间皮瘤的提出概念、其组织发生及其可能的临床相关性对这些发现进行了讨论。
