Gerhäuser Clarissa
Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany.
Mol Nutr Food Res. 2005 Sep;49(9):827-31. doi: 10.1002/mnfr.200500091.
This review summarizes the capacity of xanthohumol (XN) in comparison with additional hop constituents and metabolites to act as an antiinfective agent against microorganisms including bacteria, viruses, fungi and malarial protozoa. XN was shown to inhibit the Gram-positive bacteria Staphylococcus aureus and Streptococcus mutans. Antiviral activity was demonstrated against bovine viral diarrhea virus, cytomegalovirus, herpes simplex virus type 1 and 2 and human immunodeficiency virus 1. Inhibition of two Trichophyton spp. was indicative of antifungal activity. Finally, XN potently inhibited the replication of Plasmodium falciparum, the causative agent of malaria. This effect was linked to the inhibition of glutathione-mediated degradation and detoxification of haemin, a by-product of the parasitic digestion of haemoglobin. Overall, these activities further contribute to the broad spectrum of biological effects observed with XN.
本综述总结了与其他啤酒花成分及代谢产物相比，黄腐酚（XN）作为抗感染剂对抗包括细菌、病毒、真菌和疟原虫在内的微生物的能力。已表明XN可抑制革兰氏阳性菌金黄色葡萄球菌和变形链球菌。还证明了其对牛病毒性腹泻病毒、巨细胞病毒、1型和2型单纯疱疹病毒以及人类免疫缺陷病毒1具有抗病毒活性。对两种毛癣菌属的抑制表明其具有抗真菌活性。最后，XN能有效抑制疟疾病原体恶性疟原虫的复制。这种作用与抑制谷胱甘肽介导的血红素降解和解毒有关，血红素是血红蛋白被寄生虫消化后的副产物。总体而言，这些活性进一步促成了XN所观察到的广泛生物学效应。
