Bennell Kim, Hinman Rana
Centre for Health, Exercise and Sports Medicine, School of Physiotherapy, University of Melbourne, Australia.
Curr Opin Rheumatol. 2005 Sep;17(5):634-40. doi: 10.1097/01.bor.0000171214.49876.38.
This review highlights recent important research, future directions, and clinical applications for exercise and osteoarthritis. It focuses on knee osteoarthritis because of its prevalence and the dearth of research involving other joint osteoarthritis. The review covers exercise prescription for symptomatic relief, and its potential role in reducing development and slowing progression of osteoarthritis.
Meta-analyses support recommendations that exercise is important in osteoarthritis management. Benefits appear to be additive when exercise is delivered with other interventions such as weight loss. Mode of exercise delivery has cost implications and may influence overall outcome. It appears that supervised exercise sessions are superior to home exercises for pain reduction. The challenge remains to increase the proportion of patients exercising. Areas of emerging interest are exercise to prevent disease or slow its progression and recognition of patient subgroups that may respond differently to treatment. Based on studies showing a relation between weaker quadriceps strength and increased risk of developing knee osteoarthritis, particularly in women, strength training may be able to prevent knee osteoarthritis. Novel exercise programs that strengthen hip muscles or alter impairments in knee neuromuscular control may also influence disease progression.
Future studies must identify cost-effective exercise modes, strategies to maximize exercise compliance and optimal treatment combinations. The role of muscle strength and altered neuromuscular control in the prevention and development of osteoarthritis must be evaluated with the view to devising and testing novel exercise interventions.
本综述重点介绍运动与骨关节炎的近期重要研究、未来方向及临床应用。鉴于膝关节骨关节炎的患病率以及涉及其他关节骨关节炎研究的匮乏,本文主要聚焦于膝关节骨关节炎。综述涵盖了用于缓解症状的运动处方,以及其在减少骨关节炎发生和延缓病情进展方面的潜在作用。
荟萃分析支持运动在骨关节炎管理中具有重要作用的建议。当运动与其他干预措施(如减肥)相结合时,其益处似乎具有叠加性。运动实施方式具有成本影响,可能会影响总体结果。似乎监督下的运动课程在减轻疼痛方面优于家庭锻炼。提高运动患者的比例仍是一项挑战。新出现的研究热点包括预防疾病或延缓其进展的运动,以及识别可能对治疗反应不同的患者亚组。基于研究表明股四头肌力量较弱与患膝关节骨关节炎风险增加之间存在关联,尤其是在女性中,力量训练可能能够预防膝关节骨关节炎。加强髋部肌肉或改变膝关节神经肌肉控制障碍的新型运动计划也可能影响疾病进展。
未来的研究必须确定具有成本效益的运动方式、提高运动依从性的策略以及最佳治疗组合。必须评估肌肉力量和改变的神经肌肉控制在骨关节炎预防和发展中的作用,以便设计和测试新型运动干预措施。