Holterman Chet E, Rudnicki Michael A
Ottawa Health Research Institute, Molecular Medicine Program, Ottawa, Ontario, Canada K1H 8L6.
Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):575-84. doi: 10.1016/j.semcdb.2005.07.004.
Quiescent satellite cells are responsible for the repair of post-natal skeletal muscle. These cells are easily identified by their unique morphology within skeletal muscle as well as by several recently elucidated molecular markers. Careful examination of the function of these markers has provided insight into the early events surrounding satellite cell specification and activation. However, the origin of these cells, as well as the mechanisms by which this population is maintained within the adult remain elusive. Furthermore, the ability of non-muscle derived stem cells and the potential multipotency of satellite cells have altered the traditional views of skeletal muscle regeneration.
静止的卫星细胞负责出生后骨骼肌的修复。这些细胞通过其在骨骼肌内独特的形态以及最近阐明的几种分子标记物很容易被识别。对这些标记物功能的仔细研究为卫星细胞特化和激活周围的早期事件提供了深入了解。然而，这些细胞的起源以及该群体在成体中维持的机制仍然难以捉摸。此外，非肌肉来源干细胞的能力以及卫星细胞的潜在多能性改变了骨骼肌再生的传统观点。
