间歇抗阻训练对肥胖男性肌肉因子和心血管危险因素的强度依赖性影响。

Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity.

机构信息

Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.

出版信息

Front Endocrinol (Lausanne). 2022 Jun 10;13:895512. doi: 10.3389/fendo.2022.895512. eCollection 2022.

DOI:10.3389/fendo.2022.895512

PMID:35757424

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9226680/

Abstract

OBJECTIVE

To determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 [TGF-β1]), and cardiometabolic and anthropometric measures in males with obesity.

METHODS

Forty-four obese males (age: 27.5 ± 9.4 yr.; height: 165.4 ± 2.8 cm; weight: 97.9 ± 2.6 kg and BMI: 35.7 ± 4.3 kg/m) were randomly assigned to one of four groups (n=11 per group): low-intensity interval resistance training (LIIRT), moderate-intensity interval resistance training (MIIRT), high-intensity interval resistance training (HIIRT) or control (C). The LIIRT group performed 10 exercises in 3 sets of 40% (20 repetitions), the MIIRT group performed 10 exercises in three sets of 60% (13 repetitions), and the HIIRT group performed 10 exercises in three sets of 80% (10 repetitions) of one maximum repetition (1RM), which were followed with active rest of 20% of 1RM and 15 repetitions. The resistance training groups exercised ~70 min per session, 3 days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of exercise training.

RESULTS

Baseline levels of myokines, cardiovascular risk factors, anthropometry, body composition, and cardio-respiratory fitness were not different between the four groups (p>0.05). The group x time interactions for decorin, activin A, follistatin, myostatin, and TGF-β1, total cholesterol (TC), triglyceride (TG), high-density cholesterol (HDL), low-density cholesterol (LDL), anthropometry, body composition, and cardio-respiratory fitness were statistically significant (p<0.05). There were increases in post-test values for decorin, follistatin, HDL (p<0.05) and decreases in TC, TG, TGF-β1, LDL, and myostatin levels in the LIIRT, MIIRT, and HIIRT groups compared to pretest values (p<0.05). Changes in fat mass, VO HDL, TG, glucose, activin A, decorin were not significant in LIIRT compared to the control group, while changes in activin A, follistatin, and TFG-β1 levels were greater in HIIRT and MIIRT groups compared to the LIIRT group (p<0.05).

CONCLUSION

The LIIRT, MIIRT, and HIIRT protocols all produced beneficial changes in decorin, activin A, follistatin, myostatin, and TGF-β1 levels, and cardiometabolic risk factors, with greater effects from the MIIRT and HIIRT protocols compared to LIIRT.

摘要

目的

确定不同强度间歇抗阻训练（IRT）方案对肥胖男性中选定的肌肉因子（核心蛋白聚糖、激活素 A、转化生长因子-β1[TGF-β1]）水平以及心脏代谢和人体测量指标的影响。

方法

44 名肥胖男性（年龄：27.5±9.4 岁；身高：165.4±2.8cm；体重：97.9±2.6kg 和 BMI：35.7±4.3kg/m）被随机分配到四个组之一（每组 11 人）：低强度间歇抗阻训练（LIIRT）、中等强度间歇抗阻训练（MIIRT）、高强度间歇抗阻训练（HIIRT）或对照组（C）。LIIRT 组进行 10 项运动，3 组，每组 40%（20 次重复），MIIRT 组进行 10 项运动，3 组，每组 60%（13 次重复），HIIRT 组进行 10 项运动，3 组，每组 80%（10 次重复）1RM，然后进行主动休息 20%的 1RM 和 15 次重复。阻力训练组每次训练约 70 分钟，每周 3 天，共 12 周。在基线和 12 周的运动训练后进行测量。

结果

四组间肌肉因子、心血管危险因素、人体测量、身体成分和心肺功能的基线水平无差异（p>0.05）。核心蛋白聚糖、激活素 A、卵泡抑素、肌肉生长抑制素和 TGF-β1、总胆固醇（TC）、甘油三酯（TG）、高密度胆固醇（HDL）、低密度胆固醇（LDL）、人体测量、身体成分和心肺功能的组间 x 时间交互作用具有统计学意义（p<0.05）。与术前相比，LIIRT、MIIRT 和 HIIRT 组的术后值增加了核心蛋白聚糖、卵泡抑素和 HDL（p<0.05），TC、TG、TGF-β1、LDL 和肌肉生长抑制素水平降低（p<0.05）。与对照组相比，LIIRT 组的脂肪量、VO HDL、TG、葡萄糖、激活素 A、核心蛋白聚糖的变化不显著，而 HIIRT 和 MIIRT 组的激活素 A、卵泡抑素和 TFG-β1 水平变化大于 LIIRT 组（p<0.05）。