Chiocca J C, Olmos J A, Salis G B, Soifer L O, Higa R, Marcolongo M
Department of Gastroenterology, Hospital Nacional Prof. Dr Alejandro Posadas, El Palomar, Buenos Aires, Argentina.
Aliment Pharmacol Ther. 2005 Aug 15;22(4):331-42. doi: 10.1111/j.1365-2036.2005.02565.x.
Population-based data on gastro-oesophageal reflux in Latin America are lacking.
To assess gastro-oesophageal reflux symptom prevalence, clinical spectrum and association with the atypical symptoms in our country.
Gastro-oesophageal reflux self-report questionnaires validated at Mayo Clinic, USA, were submitted to a sample of 1000 residents (aged 18-80 years) from 17 representative geographical areas of Argentina. The samples were selected and stratified according to age, gender, geographical areas and size of town of residence provided by the Argentine Bureau of Statistics and Census.
The overall prevalence of any typical gastro-oesophageal reflux symptom experienced in the previous year was 61.2% (95% CI, 57.9-64.6), the prevalence of frequent gastro-oesophageal reflux symptoms was 23.0% (95% CI, 20.1-25.9) and the prevalence of gastro-oesophageal reflux disease was 11.9% (95% CI, 9.6-14.1). Frequent gastro-oesophageal reflux symptoms were associated with dysphagia (OR 2.12, 95% CI, 1.27-3.54, P < 0.01), globus (OR 2.22, 95% CI, 1.35-3.66, P < 0.01) and non-cardiac chest pain (OR 1.55, 95% CI, 1.04-2.31, P < 0.05).
In Argentina, typical symptoms of gastro-oesophageal reflux are highly prevalent at the national level, and frequent gastro-oesophageal reflux symptoms are significantly associated with dysphagia, globus and non-cardiac chest pain.
拉丁美洲缺乏基于人群的胃食管反流数据。
评估我国胃食管反流症状的患病率、临床谱及其与非典型症状的关联。
将在美国梅奥诊所验证过的胃食管反流自我报告问卷提交给来自阿根廷17个代表性地理区域的1000名居民（年龄在18 - 80岁之间）。样本根据年龄、性别、地理区域以及阿根廷统计局和人口普查局提供的居住城镇规模进行选择和分层。
上一年出现任何典型胃食管反流症状的总体患病率为61.2%（95%可信区间，57.9 - 64.6），频繁胃食管反流症状的患病率为23.0%（95%可信区间，20.1 - 25.9），胃食管反流病的患病率为11.9%（95%可信区间，9.6 - 14.1）。频繁胃食管反流症状与吞咽困难（比值比2.12，95%可信区间，1.27 - 3.54，P < 0.01）、咽部异物感（比值比2.22，95%可信区间，1.35 - 3.66，P < 0.01）和非心源性胸痛（比值比1.55，95%可信区间，1.04 - 2.31，P < 0.05）相关。
在阿根廷，胃食管反流的典型症状在全国范围内高度流行，且频繁胃食管反流症状与吞咽困难、咽部异物感和非心源性胸痛显著相关。
