Choi Eung Ho, Man Mao-Qiang, Wang Fusheng, Zhang Xinjiang, Brown Barbara E, Feingold Kenneth R, Elias Peter M
Department of Dermatology, University of California, San Francisco, California, USA.
J Invest Dermatol. 2005 Aug;125(2):288-93. doi: 10.1111/j.0022-202X.2005.23799.x.
Although stratum corneum (SC) hydration has been primarily of concern to the cosmetic industry, it serves an important biosensor function. In murine models, not only deiminated products of filaggrin-derived amino acids ("NMF") but also endogenous glycerol from circulation into the epidermis via aquaporin 3 channel and from triglyceride turnover in sebaceous glands (SG) are important determinants. We assessed here whether endogenous glycerol could also be linked to SC hydration in humans. SG-enriched sites are more hydrated than SG-impoverished sites, and SC hydration correlates with both sebum production and SC glycerol content, but the correlation is more significant for SC glycerol content than for sebum content. Moreover, gender-related differences in sebum content are not associated with altered SC hydration. SC hydration is also linked to SC glycerol content in SG-impoverished sites, suggesting a role for non-SG-derived (? from circulation) glycerol in SC hydration. Finally, short-term water immersion produces a parallel decline in SC hydration and SC glycerol content, with glycerol levels returning to normal over several hours. These results suggest that endogenous glycerol of both circulatory and SG origin comprises an H2O-extractable pool that influences SC hydration in humans. These results also provide a rationale for the development of glycerol-containing therapeutic moisturizers.
尽管角质层（SC）水合作用主要是化妆品行业关注的问题，但它具有重要的生物传感器功能。在小鼠模型中，不仅丝聚蛋白衍生氨基酸的去氨化产物（“天然保湿因子”），而且通过水通道蛋白3通道从循环进入表皮的内源性甘油以及皮脂腺（SG）中甘油三酯周转产生的内源性甘油都是重要的决定因素。我们在此评估内源性甘油是否也与人类的SC水合作用有关。富含SG的部位比缺乏SG的部位水分含量更高，并且SC水合作用与皮脂分泌和SC甘油含量均相关，但SC甘油含量的相关性比皮脂含量更为显著。此外，皮脂含量的性别差异与SC水合作用的改变无关。在缺乏SG的部位，SC水合作用也与SC甘油含量相关，这表明非SG来源（？来自循环）的甘油在SC水合作用中发挥作用。最后，短期水浸会导致SC水合作用和SC甘油含量同时下降，甘油水平在数小时内恢复正常。这些结果表明，循环和SG来源的内源性甘油都包含一个可被水提取的池，它会影响人类的SC水合作用。这些结果也为开发含甘油的治疗性保湿剂提供了理论依据。
