Fanikos John, Grasso-Correnti Nicole, Shah Ravi, Kucher Nils, Goldhaber Samuel Z
Department of Pharmacy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Am J Cardiol. 2005 Aug 15;96(4):595-8. doi: 10.1016/j.amjcard.2005.03.104.
Major bleeding complications were investigated in 2,460 patients with 3,684 patient-years of warfarin exposure from 2000 to 2003. The most common indications for anticoagulation were atrial fibrillation (30%), venous thromboembolic disease (28%), and mechanical heart valve prosthesis (15%). Eleven patients had 12 nonfatal major bleeding complications, with no fatal bleeds during the study. The incidence of major bleeding complications was 0.12%/year; there were 0.32 bleeds/100 patient-years of coverage. Of the 12 bleeding events, 5 (42%) were intracranial hemorrhages. The average hospitalization cost per patient was dollar 15,988, and the average length of hospitalization was 6.0 days.
对2000年至2003年期间2460例接受华法林治疗达3684患者年的患者进行了严重出血并发症的调查。抗凝治疗最常见的适应证是心房颤动（30%）、静脉血栓栓塞性疾病（28%）和机械心脏瓣膜置换术（15%）。11例患者发生了12次非致命性严重出血并发症，研究期间无致命性出血。严重出血并发症的发生率为0.12%/年；每100患者年有0.32次出血。在12次出血事件中，5次（42%）为颅内出血。每位患者的平均住院费用为15988美元，平均住院时间为6.0天。
