Sram Radim J, Binkova Blanka, Lnenickova Zdena, Solansky Ivo, Dejmek Jan
Institute of Experimental Medicine Academy of Sciences of Czech Republic, Health Institute of Central Bohemia, Videnska 1083, 14220 Prague 4, Czech Republic.
Mutat Res. 2005 Dec 11;591(1-2):302-10. doi: 10.1016/j.mrfmmm.2005.04.015. Epub 2005 Aug 15.
Folate plays an important role in the genomic stability of human cells. In our studies of the impact of environmental pollution on human health, we have found that air pollution can affect pregnancy outcome. As it may be also affected by nutrition, we examined the effect of plasma folate levels of mothers and newborns on intrauterine growth retardation (IUGR) and birth weight (BW) in cohorts from Prague (N=319) and Teplice (N=444). The lower plasma levels (<6.1 nmol/L) were observed in 7.1% of mothers in Prague, and in 9.6% of mothers in Teplice. The higher plasma levels (>36.5 nmol/L) were observed in 28.4% of mothers in Prague, and in 15.7% of mothers in Teplice. The higher plasma levels were observed in 75.4% of newborns in Prague, and 73.2% of newborns in Teplice. When comparing maternal high versus low folate plasma levels and IUGR by logistic regression, the risk of IUGR was significantly decreased for European cohort (according to ethnicity) with gestation age >36 weeks [N=536, OR=0.44, P=0.026], and even more pronounced in the group of European smokers [N=157, OR=0.14, P=0.015]. Using multiple regression analysis, plasma folate levels of mothers and newborns significantly affected the birth weight of newborns of smoking mothers (P<0.05). The obtained results seem to indicate a positive effect of folate on pregnancy outcome, especially its potential to decrease the risk of IUGR in European population and lower birth weight in smoking European mothers. It would be warranted to study the effect of folate levels on pregnancy outcomes in the relationship to different environmental pollution and life styles of mothers.
叶酸在人类细胞的基因组稳定性中起着重要作用。在我们关于环境污染对人类健康影响的研究中，我们发现空气污染会影响妊娠结局。由于其也可能受营养影响，我们在来自布拉格（N = 319）和特普利采（N = 444）的队列中，研究了母亲和新生儿血浆叶酸水平对宫内生长受限（IUGR）和出生体重（BW）的影响。在布拉格，7.1%的母亲血浆水平较低（<6.1 nmol/L），在特普利采，这一比例为9.6%。在布拉格，28.4%的母亲血浆水平较高（>36.5 nmol/L），在特普利采，这一比例为15.7%。在布拉格，75.4%的新生儿血浆水平较高，在特普利采，这一比例为73.2%。通过逻辑回归比较母亲叶酸血浆水平高与低和IUGR时，对于孕周>36周的欧洲队列（按种族划分）[N = 536，OR = 0.44，P = 0.026]，IUGR风险显著降低，在欧洲吸烟组中更为明显[N = 157，OR = 0.14，P = 0.015]。使用多元回归分析，母亲和新生儿的血浆叶酸水平显著影响吸烟母亲新生儿的出生体重（P<0.05）。所得结果似乎表明叶酸对妊娠结局有积极影响，特别是其降低欧洲人群IUGR风险以及吸烟欧洲母亲低出生体重风险的潜力。研究叶酸水平与母亲不同环境污染和生活方式关系下对妊娠结局的影响是有必要的。
