Simon John W, O'Malley Martin R, Gandham Sai B, Ghaiy Rajat, Zobal-Ratner Jitka, Simmons Steven T
Department of Ophthalmology/Lions Eye Institute Albany Medical College Albany, New York, USA.
J AAPOS. 2005 Aug;9(4):326-9. doi: 10.1016/j.jaapos.2005.02.014.
The risk of glaucoma among aphakic children is as high as 32%, based primarily on intraocular pressure (IOP) measurements. Although IOP may be falsely elevated by increased central corneal thickness, central corneal thickness (CCT) values have not been reported in this population.
Patients from the practices of 2 pediatric ophthalmologists and 2 glaucoma specialists had measurements of CCT, IOP, and optic nerve cupping, with visual field analysis when possible. Normal fellow eyes of unilateral aphakes and pseudophakes were included as controls.
In 36 aphakic and 6 pseudophakic eyes CCT averaged 660 microns compared with 576 microns for phakic fellow eyes (P < 0.0001). Glaucoma, defined by IOP at least 35 mm Hg or by IOP at least 22 mm Hg associated with optic nerve changes, occurred in 21% of 28 aphakic patients but in no pseudophakic patient.
CCT in aphakic/pseudophakic children is substantially increased compared with control patients. These values may be important in interpreting IOP measurements in these children.
无晶状体儿童患青光眼的风险高达32%，这主要基于眼压（IOP）测量结果。尽管中央角膜厚度增加可能会使眼压测量值出现假性升高，但该人群的中央角膜厚度（CCT）值此前尚未见报道。
来自2名儿科眼科医生和2名青光眼专家诊所的患者接受了CCT、IOP测量以及视神经杯盘比测量，必要时还进行了视野分析。单侧无晶状体眼和人工晶状体眼的正常对侧眼作为对照。
36只无晶状体眼和6只人工晶状体眼的CCT平均为660微米，而有晶状体对侧眼为576微米（P < 0.0001）。28名无晶状体患者中有21%发生了青光眼，定义为眼压至少35毫米汞柱或眼压至少22毫米汞柱并伴有视神经改变，而人工晶状体患者中无一例发生青光眼。
与对照患者相比，无晶状体/人工晶状体儿童的CCT显著增加。这些数值对于解读这些儿童的眼压测量结果可能很重要。
