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本文引用的文献

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Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus.具有1918年大流行病毒血凝素的甲型流感病毒毒力增强
Nature. 2004 Oct 7;431(7009):703-7. doi: 10.1038/nature02951.
2
Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus.来自已灭绝的1918年流感病毒的未裂解人H1血凝素的结构。
Science. 2004 Mar 19;303(5665):1866-70. doi: 10.1126/science.1093373. Epub 2004 Feb 5.
3
The structure and receptor binding properties of the 1918 influenza hemagglutinin.1918年流感血凝素的结构与受体结合特性
Science. 2004 Mar 19;303(5665):1838-42. doi: 10.1126/science.1093155. Epub 2004 Feb 5.
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1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants.1918年流感大流行由具有两种受体结合变体的高度保守病毒引起。
Emerg Infect Dis. 2003 Oct;9(10):1249-53. doi: 10.3201/eid0910.020789.
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Differences between influenza virus receptors on target cells of duck and chicken and receptor specificity of the 1997 H5N1 chicken and human influenza viruses from Hong Kong.鸭和鸡靶细胞上流感病毒受体的差异以及1997年来自香港的H5N1鸡源和人流感病毒的受体特异性
Avian Dis. 2003;47(3 Suppl):1154-60. doi: 10.1637/0005-2086-47.s3.1154.
6
Receptor-binding properties of modern human influenza viruses primarily isolated in Vero and MDCK cells and chicken embryonated eggs.主要在Vero细胞、MDCK细胞和鸡胚中分离得到的现代人流感病毒的受体结合特性。
Virology. 2003 Sep 1;313(2):473-80. doi: 10.1016/s0042-6822(03)00377-5.
7
Mutations in human parainfluenza virus type 3 hemagglutinin-neuraminidase causing increased receptor binding activity and resistance to the transition state sialic acid analog 4-GU-DANA (Zanamivir).人副流感病毒3型血凝素神经氨酸酶中的突变导致受体结合活性增加以及对过渡态唾液酸类似物4-GU-DANA（扎那米韦）产生抗性。
J Virol. 2003 Jan;77(1):309-17. doi: 10.1128/jvi.77.1.309-317.2003.
8
Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.现有的抗病毒药物对带有1918年大流行病毒基因的流感病毒有效。
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13849-54. doi: 10.1073/pnas.212519699. Epub 2002 Oct 4.
9
1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birds.1917年的禽流感病毒序列表明，1918年的大流行病毒并非直接从鸟类身上获得其血凝素。
J Virol. 2002 Aug;76(15):7860-2. doi: 10.1128/jvi.76.15.7860-7862.2002.
10
Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic.更新数据：1918 - 1920年“西班牙”流感大流行的全球死亡率
Bull Hist Med. 2002 Spring;76(1):105-15. doi: 10.1353/bhm.2002.0022.

1918年流感病毒血凝素中的单个氨基酸替换改变了受体结合特异性。

A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.

作者信息

Glaser Laurel, Stevens James, Zamarin Dmitriy, Wilson Ian A, García-Sastre Adolfo, Tumpey Terrence M, Basler Christopher F, Taubenberger Jeffery K, Palese Peter

机构信息

Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

出版信息

J Virol. 2005 Sep;79(17):11533-6. doi: 10.1128/JVI.79.17.11533-11536.2005.

DOI:10.1128/JVI.79.17.11533-11536.2005
PMID:16103207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1193621/
Abstract

The receptor binding specificity of influenza viruses may be important for host restriction of human and avian viruses. Here, we show that the hemagglutinin (HA) of the virus that caused the 1918 influenza pandemic has strain-specific differences in its receptor binding specificity. The A/South Carolina/1/18 HA preferentially binds the alpha2,6 sialic acid (human) cellular receptor, whereas the A/New York/1/18 HA, which differs by only one amino acid, binds both the alpha2,6 and the alpha2,3 sialic acid (avian) cellular receptors. Compared to the conserved consensus sequence in the receptor binding site of avian HAs, only a single amino acid at position 190 was changed in the A/New York/1/18 HA. Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor.

摘要

流感病毒的受体结合特异性可能对人类和禽流感病毒的宿主限制很重要。在此，我们表明，导致1918年流感大流行的病毒的血凝素（HA）在其受体结合特异性上存在毒株特异性差异。A/南卡罗来纳州/1/18 HA优先结合α2,6唾液酸（人类）细胞受体，而仅相差一个氨基酸的A/纽约/1/18 HA则同时结合α2,6和α2,3唾液酸（禽类）细胞受体。与禽类HA受体结合位点的保守共有序列相比，A/纽约/1/18 HA中仅第190位的一个氨基酸发生了变化。将这个单一氨基酸突变为禽类共有序列后，导致其对禽类受体产生偏好。