Fanning Thomas G, Slemons Richard D, Reid Ann H, Janczewski Thomas A, Dean James, Taubenberger Jeffery K
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850-3125, USA.
J Virol. 2002 Aug;76(15):7860-2. doi: 10.1128/jvi.76.15.7860-7862.2002.
Wild waterfowl captured between 1915 and 1919 were tested for influenza A virus RNA. One bird, captured in 1917, was infected with a virus of the same hemagglutinin (HA) subtype as that of the 1918 pandemic virus. The 1917 HA is more closely related to that of modern avian viruses than it is to that of the pandemic virus, suggesting (i) that there was little drift in avian sequences over the past 85 years and (ii) that the 1918 pandemic virus did not acquire its HA directly from a bird.
对1915年至1919年间捕获的野生水禽进行了甲型流感病毒RNA检测。1917年捕获的一只鸟感染了一种血凝素（HA）亚型与1918年大流行病毒相同的病毒。1917年的HA与现代禽流感病毒的关系比与大流行病毒的关系更为密切，这表明（i）在过去85年中禽源序列几乎没有发生漂移，以及（ii）1918年大流行病毒并非直接从鸟类获得其HA。
