Buckles G R, Smith Z D, Katz F N
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235.
Neuron. 1992 Jun;8(6):1015-29. doi: 10.1016/0896-6273(92)90124-v.
The two central photoreceptor neurons of the Drosophila eye, R7 and R8, form a retinotopic map in the optic lobe of the fly brain. We have developed a technique that allows us to visualize the projections of these neurons with high resolution. Using this technique, we have identified a new mutant, mip (more inner photoreceptors), in which this map shows a striking hyperinnervation. The extra terminals in the brain derive from an excessive recruitment of sevenless-independent R7 photoreceptor cells during eye development. The original R7, however, remains sevenless responsive. The behavior of this gene suggests that recruitment to the R7 pathway, and possibly to multiple programs in ommatidial assembly, is partially regulated by inhibition.
果蝇眼睛的两个中央光感受器神经元R7和R8，在果蝇大脑的视叶中形成视网膜拓扑图。我们开发了一种技术，能够让我们以高分辨率可视化这些神经元的投射。利用这项技术，我们鉴定出一个新的突变体mip（更多内部光感受器），在这个突变体中，该图谱显示出显著的过度神经支配。大脑中的额外终端源自眼睛发育过程中对不依赖Sevenless的R7光感受器细胞的过度招募。然而，原始的R7仍然对Sevenless有反应。该基因的行为表明，向R7通路的招募，以及可能向小眼装配中的多个程序的招募，部分受到抑制作用的调控。
