Han D K, Jeong S Y, Kim Y H, Min B G
Polymer Chemistry Laboratory, Korea Institute of Science and Technology, Seoul.
J Biomater Sci Polym Ed. 1992;3(3):229-41. doi: 10.1163/156856292x00141.
Polyurethane (PU) surface was chemically modified by grafting of perfluorodecanoic acid (PFDA) to produce a highly hydrophobic surface to compare the blood compatability with hydrophilic poly(ethylene oxide) (PEO) grafted PUs. The advancing contact angle of modified PU-PFDA was increased up to 115 deg, while that of untreated PU was 86 deg. The PFDA grafted PU exhibited less adhesion and shape change of platelets than untreated PU, and the activated partial thromboplastin time (APTT) of PU-PFDA was considerably extended. The ex vivo occlusion time of untreated PU was only 50 min, but that of PFDA grafted PU was extended to 130 min, indicating that this hydrophobic surface is significantly blood compatible. It is interesting to find that the enhanced blood compatibility of very hydrophobic PU-PFDA was equivalent to hydrophilic PU-PEO.
通过接枝全氟癸酸（PFDA）对聚氨酯（PU）表面进行化学改性，以制备高度疏水的表面，从而与亲水性聚环氧乙烷（PEO）接枝的聚氨酯比较血液相容性。改性后的PU-PFDA的前进接触角增加到115°，而未处理的PU的前进接触角为86°。与未处理的PU相比，PFDA接枝的PU表现出更少的血小板粘附和形状变化，并且PU-PFDA的活化部分凝血活酶时间（APTT）显著延长。未处理的PU的体外阻塞时间仅为50分钟，但PFDA接枝的PU的体外阻塞时间延长至130分钟，这表明这种疏水表面具有显著的血液相容性。有趣的是，发现疏水性很强的PU-PFDA增强后的血液相容性与亲水性PU-PEO相当。
