Zhu Junjia, Xu Wenlong, Sun Qi, Geng Jun, Yu Yifeng, Zhao Zhenguo
Department of General Surgery, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin 214400, China.
Department of Anesthesiology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin 214400, China.
Gastroenterol Res Pract. 2022 Jun 8;2022:8029600. doi: 10.1155/2022/8029600. eCollection 2022.
Postoperative ileus (POI) is an important complication after elective colorectal surgery, which prolongs hospital stay and increases hospital costs. Coffee has been reported to be beneficial for the recovery of gastrointestinal function. We aimed to investigate the effectiveness of coffee consumption in the treatment of POI, following elective colorectal surgery.
A comprehensive literature search for medical subject heading (MeSH) terms, including coffee, caffeine, colon, rectum, and colorectal surgery was conducted in PubMed, Embase, and Cochrane Library until November 2021. A meta-analysis of postoperative outcomes was conducted to assess the effectiveness of coffee consumption on POI after colorectal surgery.
726 articles were identified and six RCTs that captured 416 patients were included. The time to first defecation was reduced with postoperative coffee consumption compared to the control group (mean difference = -15.03 h; 95% confidence interval: -17.79, -12.26; < 0.00001). There was no difference in time to first flatus, time to tolerance for solid food, length of hospital stay, use of laxatives, reinsertion of nasogastric tube, need for reoperation, postoperative complications, and anastomotic leak between the groups. Coffee did not have any adverse effects.
The current literature revealed that postoperative coffee consumption shortened the time to first defecation following elective colorectal surgery. Large sample and tightly controlled multicenter randomized clinical trials are needed to offer a more accurate evaluation of the efficacy of coffee.
术后肠梗阻（POI）是择期结直肠手术后的一种重要并发症，它会延长住院时间并增加住院费用。据报道，咖啡有助于胃肠功能的恢复。我们旨在研究在择期结直肠手术后饮用咖啡对治疗POI的有效性。
截至2021年11月，在PubMed、Embase和Cochrane图书馆中对包括咖啡、咖啡因、结肠、直肠和结直肠手术等医学主题词（MeSH）进行了全面的文献检索。对术后结果进行荟萃分析，以评估结直肠手术后饮用咖啡对POI的有效性。
共识别出726篇文章，纳入了6项随机对照试验，涉及416例患者。与对照组相比，术后饮用咖啡可缩短首次排便时间（平均差异=-15.03小时；95%置信区间：-17.79，-12.26；P<0.00001）。两组在首次排气时间、固体食物耐受时间、住院时间、使用泻药、重新插入鼻胃管、再次手术需求、术后并发症和吻合口漏方面没有差异。咖啡没有任何不良影响。
当前文献表明，择期结直肠手术后饮用咖啡可缩短首次排便时间。需要进行大样本且严格控制的多中心随机临床试验，以更准确地评估咖啡的疗效。
