Zhang Xing-Guo, Yu Chao-Hui, Jiang Qi, Zhang Yu, Chen Shao-Hua, Lu You-Ming
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Zhongguo Zhong Yao Za Zhi. 2005 Jun;30(11):847-50.
To evaluate the effect of tea polyphenol(TP) on the rat with alcoholic liver damage.
Rats were divided into 3 groups, in which 2 groups were stomach perfused with alcohol to result in ALD, and 1 group of them stomach perfused with TP simultaneously. Another group was normal control groups (stomach perfused with drinking water). In the end of 12 weeks, the liver specimen of each rat was observed by anglicizing its tissue damage, and all data collected was performed by statistical analysis in quantum and semi-quantum. Meanwhile cytokines gene express of each group is determined.
In the end of 12 weeks, alcoholic hepatitis appeared in rat liver. Hepatic injury in alcohol group and TP group were found, but could not be found in normal group. Compared with pure alcohol group, alcoholic liver damage mainly showing with steatosis in TP group were slight, in addition showing liver cellular swelling with small area, with less spot and focal necrosis, none bridging necrosis. Steatosis were slight relatively, mega-bubble steatosis were less found. Collagen deposition of TP group were less than those of pure alcohol group. Gene expression of. cytokine have diversity statistically such as IL-3, IL-4, IL-1R2, IL-6R, IL-7R2, IL-3Ra, IL-R1, IL-13, IL-1R1, IL-7R2, EPO-R, LIFR, IL-1R2, IL-5R2, CSF1, CD27, IL-6R.
TP is able to attenuate alcoholic liver damage. It's mechanism is possibly due to modulating cytokines gene expression of cytokine.
评估茶多酚（TP）对酒精性肝损伤大鼠的影响。
将大鼠分为3组，其中2组经胃灌注酒精以导致酒精性肝损伤，其中1组同时经胃灌注TP。另一组为正常对照组（经胃灌注饮用水）。12周结束时，通过分析其组织损伤观察每只大鼠的肝脏标本，并对收集的所有数据进行定量和半定量统计分析。同时测定每组细胞因子基因表达。
12周结束时，大鼠肝脏出现酒精性肝炎。酒精组和TP组均发现肝损伤，但正常组未发现。与纯酒精组相比，TP组酒精性肝损伤主要表现为脂肪变性较轻，此外可见小面积肝细胞肿胀，点状和灶状坏死较少，无桥接坏死。脂肪变性相对较轻，大泡性脂肪变性较少见。TP组胶原沉积少于纯酒精组。细胞因子如IL-3、IL-4、IL-1R2、IL-6R、IL-7R2、IL-3Ra、IL-R1、IL-13、IL-1R1、IL-7R2、EPO-R、LIFR、IL-1R2、IL-5R2、CSF1、CD27、IL-6R的基因表达在统计学上具有多样性。
TP能够减轻酒精性肝损伤。其机制可能是由于调节细胞因子的基因表达。
