[茶多酚对大鼠肝纤维化的影响及相关机制]
[Effect of tea polyphenol on liver fibrosis in rats and related mechanism].
作者信息
Zhang Xing-guo, Yu Chao-hui, Qing Yu-e, Zhang Yu, Chen Shao-hua, Li You-ming
机构信息
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2003 Nov;28(11):1070-2.
OBJECTIVE
To investigate the effect of tea polyphenol (TP)'s on liver fibrosis in rats and its possible mechanism.
METHOD
Rats were divided into 5 groups, 4 groups of which were stomach perfused with alcohol resulting in alcoholic liver fibrosis, and 3 groups of which were stomach perfused with TP simultaneously. Another group was normal control one. Histological change of rat liver was investigated and quantitative analysis was made in 24 weeks, and rat liver anti-oxidation index and serum endotoxin were determined at the same time.
RESULT
Liver fibrosis in TP group was slight, and anti-oxidize index and endotoxin level were markedly improved in comparison with those of alcohol groups.
CONCLUSION
Tea polyphenol can protect hepatocytes from fibrosis. Its mechanism is possibly due to cleaning up overfull lipid per-oxidation and reducing the level of endotoxin.
目的
探讨茶多酚（TP）对大鼠肝纤维化的影响及其可能机制。
方法
将大鼠分为5组，其中4组经胃灌注酒精致酒精性肝纤维化，3组同时经胃灌注TP。另一组为正常对照组。24周时观察大鼠肝脏组织学变化并进行定量分析，同时测定大鼠肝脏抗氧化指标及血清内毒素。
结果
TP组肝纤维化程度较轻，与酒精组相比，抗氧化指标及内毒素水平明显改善。
结论
茶多酚可保护肝细胞免受纤维化影响。其机制可能是清除过多的脂质过氧化产物并降低内毒素水平。
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