Adriaanse Marcel C, Dekker Jacqueline M, Spijkerman Annemieke M W, Twisk Jos W R, Nijpels Giel, van der Ploeg Henk M, Heine Robert J, Snoek Frank J
Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands.
Qual Life Res. 2005 Aug;14(6):1501-9. doi: 10.1007/s11136-004-0028-3.
To determine the level of diabetes-related symptom distress and its association with negative mood in subjects participating in a targeted population-screening program, comparing those identified as having type 2 diabetes vs. those who did not.
This study was conducted within the framework of a targeted screening project for type 2 diabetes in a general Dutch population (age 50-75 years). The study sample consisted of 246 subjects, pre-selected on the basis of a high-risk profile; 116 of whom were subsequently identified as having type 2 diabetes, and 130 who were non-diabetic subjects. Diabetes-related symptom distress and negative mood was assessed approximately 2 weeks, 6 months, and 12 months after the diagnosis of type 2 diabetes, with the Type 2 Diabetes Symptom Checklist and the Negative well-being sub scale of the Well-being Questionnaire (W-BQ12), respectively.
Screening-detected diabetic patients reported significantly greater burden of hyperglycemic (F = 6.0, df = 1, p = 0.015) and of fatigue (F = 5.3, df = 1, p = 0.023) symptoms in the first year following diagnosis type 2 diabetes compared to non-diabetic subjects. These outcomes did not change over time. The total symptom distress (range 0-4) was relatively low for both screening-detected diabetic patients (median at approximately 2 weeks, 6 months, and 12 months; 0.24, 0.24, 0.29) and non-diabetic subjects (0.15, 0.15, 0.18), and not significantly different. No average difference and change over time in negative well-being was found between screening-detected diabetic patients and non-diabetic subjects. Negative well-being was significantly positive related with the total symptom distress score (regression coefficient beta = 2.86, 95% CI 2.15-3.58).
The screening-detected diabetic patients were bothered more by symptoms of hyperglycemia and fatigue in the first year following diagnosis type 2 diabetes than non-diabetic subjects. More symptom distress is associated with increased negative mood in both screening-detected diabetic patients and non-diabetic subjects.
确定参与目标人群筛查项目的受试者中与糖尿病相关的症状困扰水平及其与负面情绪的关联，比较被确诊为2型糖尿病的受试者与未患糖尿病的受试者。
本研究在荷兰普通人群（年龄50 - 75岁）的2型糖尿病目标筛查项目框架内进行。研究样本由246名基于高风险特征预先选定的受试者组成；其中116名随后被确诊为2型糖尿病，130名是非糖尿病受试者。分别在2型糖尿病诊断后约2周、6个月和12个月，使用2型糖尿病症状清单和幸福感问卷（W - BQ12）的负面幸福感子量表评估与糖尿病相关的症状困扰和负面情绪。
与非糖尿病受试者相比，筛查发现的糖尿病患者在2型糖尿病诊断后的第一年报告的高血糖症状负担（F = 6.0，自由度 = 1，p = 0.015）和疲劳症状负担（F = 5.3，自由度 = 1，p = 0.023）明显更大。这些结果随时间未发生变化。筛查发现的糖尿病患者（在约2周、6个月和12个月时的中位数分别为0.24、0.24、0.29）和非糖尿病受试者（0.15、0.15、0.18）的总症状困扰（范围0 - 4）相对较低，且无显著差异。在筛查发现的糖尿病患者和非糖尿病受试者之间，未发现负面幸福感随时间的平均差异和变化。负面幸福感与总症状困扰评分显著正相关（回归系数β = 2.86，95%置信区间2.15 - 3.58）。
筛查发现的糖尿病患者在2型糖尿病诊断后的第一年比非糖尿病受试者更容易受到高血糖和疲劳症状的困扰。在筛查发现的糖尿病患者和非糖尿病受试者中，更多的症状困扰都与负面情绪增加有关。
