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关于变异性辩论的一个新的实证视角:对来自布罗卡失语症的大数据集的定量神经句法分析。

A new empirical angle on the variability debate: quantitative neurosyntactic analyses of a large data set from Broca's aphasia.

作者信息

Drai Dan, Grodzinsky Yosef

机构信息

Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.

出版信息

Brain Lang. 2006 Feb;96(2):117-28. doi: 10.1016/j.bandl.2004.10.016. Epub 2005 Aug 22.

Abstract

Behavioral variation in Broca's aphasia has been characterized as boundless, calling into question the validity of the syndrome-based schema and related diagnostic methods of acquired language disorders. More generally, this putative variability has cast serious doubts on the feasibility of localizing linguistic operations in cortex. We present a new approach to the quantitative analysis of deficient linguistic performance, and apply it to a large data set, constructed from the published literature: Comprehension data of 69 carefully selected Broca's aphasic patients, tested on nearly 6000 stimulus sentences, were partitioned in different ways, and subjected to a series of analyses. While a certain amount of variability is indeed evident in the data, our quantitative analyses reveal a highly robust selective impairment pattern for the group: the patients' ability to analyze syntactic movement is severely compromised, in line with the Trace-Deletion Hypothesis. Further analyses suggest that patients' performance on no-movement sentence types exhibits less variation than on sentences that contain movement. We discuss the clinical and theoretical implications of our results.

摘要

布罗卡失语症的行为变异被描述为无界限的,这使得基于综合征的模式以及获得性语言障碍的相关诊断方法的有效性受到质疑。更普遍地说,这种假定的变异性严重怀疑了在皮质中定位语言操作的可行性。我们提出了一种对语言表现缺陷进行定量分析的新方法,并将其应用于一个从已发表文献构建的大型数据集:对69名精心挑选的布罗卡失语症患者的理解数据进行了分析,这些患者在近6000个刺激句子上接受了测试,数据以不同方式进行了划分,并进行了一系列分析。虽然数据中确实存在一定程度的变异性,但我们的定量分析揭示了该组患者高度稳健的选择性损伤模式:患者分析句法移动的能力严重受损,这与痕迹删除假说一致。进一步的分析表明,患者在无移动句子类型上的表现比在包含移动的句子上的表现变异更少。我们讨论了我们结果的临床和理论意义。

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