Young J C, Treadway J L
Department of Health Sciences, Sargent College of Allied Health Professions, Boston University, MA 02215.
Eur J Appl Physiol Occup Physiol. 1992;64(5):430-3. doi: 10.1007/BF00625062.
Glucose tolerance deteriorates over the course of a normal human pregnancy as a result of increased peripheral insulin resistance. In contrast, physical exercise has been shown to improve glucose tolerance and blunt the insulin response to a glucose load in insulin-resistant individuals. The purpose of this study was to determine the effect of exercise on glucose tolerance and the insulin response in healthy women during the third trimester of pregnancy (33 weeks of gestation). Five subjects underwent oral glucose tolerance tests (a) 30 min following a 30-min exercise bout on a cycle ergometer at a relative intensity of 50% maximal aerobic capacity, and (b) on a control day without prior exercise. The area under the glucose concentration curve was not different between trials, while the area under the insulin concentration curve was decreased by 23% in the exercise trial compared with the control trial (P less than 0.05). These results suggest that the insulin response to a glucose load is improved in late gestational women by a single bout of moderate intensity exercise.
由于外周胰岛素抵抗增加，正常人类孕期的糖耐量会逐渐恶化。相比之下，体育锻炼已被证明可改善糖耐量，并减弱胰岛素抵抗个体对葡萄糖负荷的胰岛素反应。本研究的目的是确定运动对妊娠晚期（妊娠33周）健康女性糖耐量和胰岛素反应的影响。五名受试者接受了口服葡萄糖耐量试验：(a) 在以50%最大有氧能力的相对强度在自行车测力计上进行30分钟运动 bout 后30分钟，以及(b) 在没有事先运动的对照日。试验之间葡萄糖浓度曲线下面积没有差异，而与对照试验相比，运动试验中胰岛素浓度曲线下面积减少了23%（P小于0.05）。这些结果表明，单次中等强度运动可改善妊娠晚期女性对葡萄糖负荷的胰岛素反应。
