Kaukonen K, Savolainen J, Viander M, Terho E O
Department of Clinical Allergology, University of Turku, Finland.
Clin Exp Immunol. 1994 Jan;95(1):162-5. doi: 10.1111/j.1365-2249.1994.tb06031.x.
Farmer's lung disease (FL), the commonest form of allergic alveolitis caused by repeated inhalation of mouldy hay, is associated with exposure to the fungus Aspergillus umbrosus among Finnish farmers. The antigen-binding avidity of A. umbrosus-specific IgG antibodies was measured in 12 FL patients in acute phases of initial and recurrent attacks and during 1 year follow up as well as in 12 healthy farmers and five healthy urban controls. The farmers' groups were further divided into two subgroups: subjects with short exposure (< 7 years) and subjects with long exposure (> 25 years). During the first acute phase FL patients with long exposure exhibited a high avidity of A. umbrosus-specific IgG antibodies that remained high during the 1 year follow up, although the A. umbrosus-specific IgG antibody titre decreased. A re-exposure to mouldy hay leading to a recurrence further enhanced the maturation of the antibody avidity, so that an even higher A. umbrosus-specific IgG avidity with a less significant increase of antibody titre occurred than during the first acute attack. Notably higher IgG antibody avidity was observed in FL patients with long exposure than in healthy farmers or in healthy controls.
农民肺（FL）是由反复吸入发霉干草引起的最常见的过敏性肺泡炎形式，在芬兰农民中与接触荫生曲霉有关。在12例初次发作和复发急性期以及1年随访期的FL患者、12例健康农民和5例健康城市对照中，检测了荫生曲霉特异性IgG抗体的抗原结合亲和力。农民组进一步分为两个亚组：短期接触（<7年）者和长期接触（>25年）者。在初次急性期，长期接触的FL患者表现出荫生曲霉特异性IgG抗体的高亲和力，尽管荫生曲霉特异性IgG抗体滴度下降，但在1年随访期间仍保持较高水平。再次接触发霉干草导致复发进一步增强了抗体亲和力的成熟，因此与初次急性发作相比，出现了更高的荫生曲霉特异性IgG亲和力，而抗体滴度的增加不太明显。长期接触的FL患者中观察到的IgG抗体亲和力明显高于健康农民或健康对照。
