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Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

作者信息

Bao L, Gerard N P, Eddy R L, Shows T B, Gerard C

机构信息

Ina Sue Perlmutter Laboratory, Children's Hospital, Boston, Massachusetts.

出版信息

Genomics. 1992 Jun;13(2):437-40. doi: 10.1016/0888-7543(92)90265-t.

DOI:10.1016/0888-7543(92)90265-t
PMID:1612600
Abstract

The genes encoding receptors for the chemotactic ligands C5a (C5AR) and FMLP (FPR) were mapped using a panel of somatic cell hybrids to chromosome 19. Because the hybridization pattern on Southern analysis suggested an intron structure or related genes in the case of FPR, genomic clones were characterized. Two structural homologues of the FMLP receptor, clones 81 (FPRH1) and 82 (FPRH2), were identified, which similarly map to chromosome 19. The structural homologues do not recognize the ligand FMLP, but are likely chemotactic receptors.

摘要

相似文献

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Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.
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J Biol Chem. 1995 Nov 17;270(46):27829-33. doi: 10.1074/jbc.270.46.27829.

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