Rawal Yeshwant B, Angiero Francesca, Allen Carl M, Kalmar John R, Sedghizadeh Parish P, Steinhilber Andrew M
Department of Oral and Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
Oral Oncol. 2006 Feb;42(2):123-30. doi: 10.1016/j.oraloncology.2005.04.016. Epub 2005 Aug 29.
The clinical, radiographic and histopathologic features of seven cases of osteoblastoma of the jaw bones were analyzed. The mandible was involved in six cases and a periosteal presentation of the tumor was noted in three cases. Six tumors were symptomatic with pain being the common presentation. The radiographic appearance of the intraosseous tumors varied from well-defined radiolucencies to poorly-defined mixed lesions. A small periosteal tumor was undetectable radiographically. Histopathologically, the tumors exhibited variation in woven bone formation, osteoblastic rimming, lesional maturation as well as interaction of the tumor with surrounding host tissue. Intraosseous tumors were managed with aggressive surgical curettage and periosteal tumors were resected and the underlying bone was curetted down to normal host bone. Follow-up of cases ranged from 2 years to 18 years with no recorded recurrences. Gnathic osteoblastomas offer a unique diagnostic challenge as they resemble other tumors of the jaws including the cementoblastoma, cemento-ossifying fibroma, cemento-osseous dysplasia and most importantly the gnathic osteosarcoma. We stress on the need to correlate the histopathologic findings with clinical and radiographic features to reach an accurate diagnosis.
对7例颌骨骨母细胞瘤的临床、影像学和组织病理学特征进行了分析。6例累及下颌骨，3例可见肿瘤的骨膜表现。6例肿瘤有症状，常见表现为疼痛。骨内肿瘤的影像学表现从边界清晰的透光区到边界不清的混合性病变不等。一个小的骨膜肿瘤在影像学上无法检测到。组织病理学上，肿瘤在编织骨形成、成骨细胞边缘、病变成熟以及肿瘤与周围宿主组织的相互作用方面表现出差异。骨内肿瘤采用积极的手术刮除治疗，骨膜肿瘤切除，刮除下方的骨直至正常宿主骨。病例随访时间为2年至18年，无复发记录。颌骨骨母细胞瘤带来了独特的诊断挑战，因为它们与其他颌骨肿瘤相似，包括成牙骨质细胞瘤、牙骨质化纤维瘤、牙骨质骨发育异常，最重要的是颌骨骨肉瘤。我们强调需要将组织病理学结果与临床和影像学特征相结合以做出准确诊断。
