Friedman B C, Bekes C E, Scott W E, Bartter T
Division of Pulmonary and Critical Care Medicine, Cooper Hospital, University Medical Center, Camden, NJ.
Intensive Care Med. 1992;18(2):123-4. doi: 10.1007/BF01705046.
Lithium is a two-edged sword; it is on the one hand a unique drug with invaluable psychoactive potential and on the other a drug which can cause multisystem toxicity and even death. We present a case of severe lithium intoxication with multiple organ involvement. Our patient developed the adult respiratory distress syndrome (ARDS), nephrogenic diabetes insipidus (DI), distinctive neurological abnormalities, and hyperglycemia. We believe that this is a case of ARDS due to lithium toxicity in which elevated left atrial pressures were excluded by right heart catheterization and suggest a causal relationship between lithium and ARDS.
锂是一把双刃剑；一方面，它是一种具有宝贵精神活性潜力的独特药物，另一方面，它又是一种可导致多系统毒性甚至死亡的药物。我们报告一例锂严重中毒伴多器官受累的病例。我们的患者出现了成人呼吸窘迫综合征（ARDS）、肾性尿崩症（DI）、明显的神经异常和高血糖。我们认为这是一例因锂中毒导致的ARDS病例，通过右心导管检查排除了左心房压力升高，并提示锂与ARDS之间存在因果关系。
