Williams John V, Crowe James E, Enriquez Rachel, Minton Patricia, Peebles R Stokes, Hamilton Robert G, Higgins Stanley, Griffin Marie, Hartert Tina V
Departments of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA.
J Infect Dis. 2005 Oct 1;192(7):1149-53. doi: 10.1086/444392. Epub 2005 Aug 29.
We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P=.03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.
我们确定了因急性哮喘加重住院后前瞻性入组的成年哮喘患者中人类偏肺病毒（hMPV）感染的患病率。入院时及出院后3个月采集的鼻腔冲洗标本通过实时逆转录聚合酶链反应检测hMPV。101名受试者中7名（6.9%）在住院时检测到hMPV，75名受试者中1名（1.3%）在随访时检测到hMPV（比值比，7[95%置信区间，0.9 - 312]；P = 0.03）。住院时感染hMPV的患者在随访时均未检测呈阳性，强烈提示hMPV在急性哮喘加重中起直接病因作用。
