Tytgat G N J
Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam Zuidoost, The Netherlands.
Eur J Surg Suppl. 2002(587):77-81.
A true comparison of long-term medical and surgical treatment in gastro-oesophageal reflux disease (GORD) is impossible as few studies have been carried out with adequate randomisation of the patients and long-term evaluation of quality of life. In general the control of the reflux symptoms is roughly equal with medical and surgical treatment. However, surgery can cause other symptoms such as dysphagia or non-specific epigastric discomfort or pain in some patients, which reduces the overall efficacy in controlling the symptoms. Based on a cost utility analysis, Heudebert et al. came to the conclusion that medical treatment was their preferred strategy for most patients with severe erosive oesophagitis.
由于很少有研究对胃食管反流病（GORD）患者进行充分随机分组并对生活质量进行长期评估，因此无法对GORD的长期药物治疗和手术治疗进行真正的比较。一般来说，药物治疗和手术治疗在控制反流症状方面大致相当。然而，手术可能会在一些患者中引发其他症状，如吞咽困难或非特异性上腹部不适或疼痛，这降低了控制症状的总体疗效。基于成本效益分析，休德伯特等人得出结论，对于大多数患有严重糜烂性食管炎的患者来说，药物治疗是他们首选的策略。
