Bytzer P, Blum A L
Department of Medical Gastroenterology, Glostrup University Hospital, Glostrup, Denmark.
Aliment Pharmacol Ther. 2004 Aug 15;20(4):389-98. doi: 10.1111/j.1365-2036.2004.02093.x.
Gastro-oesophageal reflux disease and non-erosive reflux disease are chronic, highly prevalent conditions requiring long-term treatment that is both effective and practical. On-demand therapy with a proton pump inhibitor may meet that need. It is becoming a mainstay of long-term treatment because it reduces the risk of over- and under-treatment, is cost-effective and user friendly. Epidemiological and clinical observations speak also in its favour. However, for the anticipated benefits of on-demand therapy to accrue in clinical practice, on-demand treatment algorithms are required. These algorithms must specify the initial evaluation and treatment of candidates, and follow-up protocols for an on-demand strategy. Our group has developed such algorithms, which are presented here.
胃食管反流病和非糜烂性反流病是慢性、高发性疾病，需要长期进行有效且实用的治疗。质子泵抑制剂按需治疗可能满足这一需求。它正成为长期治疗的主要手段，因为它降低了治疗过度和不足的风险，具有成本效益且使用方便。流行病学和临床观察结果也支持这一点。然而，为了使按需治疗在临床实践中产生预期效益，需要有按需治疗算法。这些算法必须明确候选者的初始评估和治疗，以及按需策略的随访方案。我们团队已经开发了此类算法，在此予以介绍。
