Diggle Mathew A, Clarke Stuart C
Scottish Meningococcus and Pneumococcus Reference Laboratory, Stobhill Hospital, Glasgow, UK.
J Clin Microbiol. 2005 Sep;43(9):4649-53. doi: 10.1128/JCM.43.9.4649-4653.2005.
During the 1990s, the incidence of meningococcal disease was high in the United Kingdom. This was due primarily to an increase in serogroup C disease, particularly that within the ET-37/ST-11 genetic lineage. Serogroup C meningococcal polysaccharide conjugate vaccines were introduced in the United Kingdom in 1999, but the sequence types of meningococci causing disease since that time have not yet been reported. We have used serogrouping and multilocus sequence typing to characterize meningococci from patients with invasive disease over a 4-year period and show that there is a significant increase in genetic diversity but no genetic evidence of capsule switching.
在20世纪90年代，英国的脑膜炎球菌病发病率很高。这主要是由于C群疾病的增加，特别是ET-37/ST-11基因谱系内的疾病。1999年，C群脑膜炎球菌多糖结合疫苗在英国投入使用，但自那时以来引起疾病的脑膜炎球菌的序列类型尚未见报道。我们利用血清分组和多位点序列分型技术，对4年期间侵袭性疾病患者的脑膜炎球菌进行了特征分析，结果表明遗传多样性显著增加，但没有荚膜转换的遗传学证据。
