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本文引用的文献

1
Laboratory diagnostic aspects of drug resistant tuberculosis.耐药结核病的实验室诊断方面
Front Biosci. 2004 Sep 1;9:2086-105. doi: 10.2741/1290.
2
Increased Interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis.医护人员中CD8和γδ T细胞产生的白细胞介素-4增加与随后活动性肺结核的发生有关。
J Infect Dis. 2004 Aug 15;190(4):756-66. doi: 10.1086/422532. Epub 2004 Jul 13.
3
Comparative evaluation of the new version of the INNO-LiPA Mycobacteria and genotype Mycobacterium assays for identification of Mycobacterium species from MB/BacT liquid cultures artificially inoculated with Mycobacterial strains.对新版本的INNO-LiPA分枝杆菌检测和基因型分枝杆菌检测进行比较评估，以从人工接种分枝杆菌菌株的MB/BacT液体培养物中鉴定分枝杆菌种类。
J Clin Microbiol. 2004 Jul;42(7):3083-8. doi: 10.1128/JCM.42.7.3083-3088.2004.
4
Direct detection of multidrug-resistant Mycobacterium tuberculosis in clinical specimens in low- and high-incidence countries by line probe assay.在结核病高发病率和低发病率国家通过线性探针分析法直接检测临床标本中的耐多药结核分枝杆菌
J Clin Microbiol. 2003 Sep;41(9):4454-6. doi: 10.1128/JCM.41.9.4454-4456.2003.
5
Rapid detection of mutations in rpoB gene of rifampicin resistant Mycobacterium tuberculosis strains by line probe assay.采用线性探针分析法快速检测耐利福平结核分枝杆菌菌株rpoB基因的突变
Indian J Med Res. 2003 Feb;117:76-80.
6
Use of molecular methods to identify the Mycobacterium tuberculosis complex (MTBC) and other mycobacterial species and to detect rifampin resistance in MTBC isolates following growth detection with the BACTEC MGIT 960 system.使用分子方法鉴定结核分枝杆菌复合群（MTBC）及其他分枝杆菌菌种，并在用BACTEC MGIT 960系统检测到MTBC分离株生长后检测其对利福平的耐药性。
J Clin Microbiol. 2003 Jul;41(7):2822-6. doi: 10.1128/JCM.41.7.2822-2826.2003.
7
The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis.结核分枝杆菌对异烟肼、利福平及吡嗪酰胺耐药性的分子基础
Respir Res. 2001;2(3):164-8. doi: 10.1186/rr54. Epub 2001 Apr 5.
8
Molecular characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Hungary by DNA sequencing and the line probe assay.通过DNA测序和线性探针分析对匈牙利结核分枝杆菌利福平耐药菌株进行分子特征分析
J Clin Microbiol. 2001 Oct;39(10):3736-9. doi: 10.1128/JCM.39.10.3736-3739.2001.
9
Laboratory diagnosis of mycobacterial infections: new tools and lessons learned.分枝杆菌感染的实验室诊断：新工具与经验教训
Clin Infect Dis. 2001 Sep 15;33(6):834-46. doi: 10.1086/322607. Epub 2001 Aug 13.
10
Access to newer laboratory procedures: a call for action.获取更新的实验室程序：行动呼吁。
Int J Tuberc Lung Dis. 2000 Dec;4(12 Suppl 2):S171-5.

在耐多药结核病高发地区，将INNO-LiPA Rif.TB线性探针检测法直接应用于360份涂片阳性呼吸道标本，以快速鉴定结核分枝杆菌复合群菌株并检测利福平耐药性。

Direct application of the INNO-LiPA Rif.TB line-probe assay for rapid identification of Mycobacterium tuberculosis complex strains and detection of rifampin resistance in 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis.

作者信息

Viveiros Miguel, Leandro Clara, Rodrigues Liliana, Almeida Josefina, Bettencourt Rosário, Couto Isabel, Carrilho Lurdes, Diogo José, Fonseca Ana, Lito Luís, Lopes João, Pacheco Teresa, Pessanha Mariana, Quirim Judite, Sancho Luísa, Salfinger Max, Amaral Leonard

机构信息

Unidade de Micobacterias do Instituto de Higiene e Medicina Tropical, Lisboa, Portugal.

出版信息

J Clin Microbiol. 2005 Sep;43(9):4880-4. doi: 10.1128/JCM.43.9.4880-4884.2005.

DOI:10.1128/JCM.43.9.4880-4884.2005
PMID:16145166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1234138/
Abstract

The INNO-LiPA Rif.TB assay for the identification of Mycobacterium tuberculosis complex strains and the detection of rifampin (RIF) resistance has been evaluated with 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis (MDR-TB). The sensitivity when compared to conventional identification/culture methods was 82.2%, and the specificity was 66.7%; the sensitivity and specificity were 100.0% and 96.9%, respectively, for the detection of RIF resistance. This assay has the potential to provide rapid information that is essential for the effective management of MDR-TB.

摘要

采用INNO-LiPA Rif.TB检测法对结核分枝杆菌复合群菌株进行鉴定并检测利福平（RIF）耐药性，该检测法已在耐多药结核病（MDR-TB）高发地区的360份涂片阳性呼吸道标本中进行了评估。与传统鉴定/培养方法相比，其灵敏度为82.2%，特异性为66.7%；检测RIF耐药性的灵敏度和特异性分别为100.0%和96.9%。该检测法有可能提供快速信息，这对MDR-TB的有效管理至关重要。