O'Keefe John, Burgess Neil
Department of Anatomy and Developmental Biology, University College London.
Hippocampus. 2005;15(7):853-66. doi: 10.1002/hipo.20115.
We review the ideas and data behind the hypothesis that hippocampal pyramidal cells encode information by their phase of firing relative to the theta rhythm of the EEG. Particular focus is given to the further hypothesis that variations in firing rate can encode information independently from that encoded by firing phase. We discuss possible explanation of the phase-precession effect in terms of interference between two independent oscillatory influences on the pyramidal cell membrane potential, and the extent to which firing phase reflects internal dynamics or external (environmental) variables. Finally, we propose a model of the firing of the recently discovered "grid cells" in entorhinal cortex as part of a path-integration system, in combination with place cells and head-direction cells.
我们回顾了这样一种假说背后的观点和数据，即海马体锥体细胞通过其相对于脑电图θ节律的放电相位来编码信息。我们特别关注进一步的假说，即放电频率的变化可以独立于放电相位所编码的信息来编码信息。我们从对锥体细胞细胞膜电位的两种独立振荡影响之间的干扰角度，讨论了相位进动效应的可能解释，以及放电相位反映内部动态或外部（环境）变量的程度。最后，我们提出了一种关于内嗅皮层中最近发现的“网格细胞”放电的模型，作为路径整合系统的一部分，该系统与位置细胞和头部方向细胞相结合。
