Leibovitch Igal, Kurtz Shimon, Kesler Anat, Feithliher Nataly, Shemesh Gabi, Sela Ben-Ami
Department of Ophthalmology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
J Glaucoma. 2005 Oct;14(5):384-6. doi: 10.1097/01.ijg.0000176932.06606.6e.
To determine C-reactive protein (CRP) levels in patients with normal tension glaucoma (NTG).
This study included 20 cases with NTG and 30 controls, with no history of ocular disease. Plasma CRP levels of all the study participants were determined using a highly sensitive CRP kit.
Twenty cases (11 males, 9 females, mean age 69 +/- 5 years) with NTG and 30 age-matched controls (15 males, 15 females, mean age 68 +/- 6) were evaluated. Both groups had similar demographic parameters (age, sex, BMI). Plasma CRP levels were significantly higher in the NTG cases than in controls (median [range], 3.20 [0.17-8.4] mg/dL compared with 0.5 [0.1-3.2], P < 0.001). The mean plasma CRP level was significantly elevated in the NTG cases compared with the controls (3.21 +/- 0.6 mg/dL and 0.85 +/- 0.17 mg/dL, respectively, P < 0 0.01).
Our findings suggest that higher CRP levels may be associated with NTG. It is possible that a vascular inflammatory process is involved in the etiology of this glaucoma.
测定正常眼压性青光眼（NTG）患者的C反应蛋白（CRP）水平。
本研究纳入20例NTG患者和30名对照者，对照者无眼部疾病史。使用高敏CRP试剂盒测定所有研究参与者的血浆CRP水平。
对20例NTG患者（11例男性，9例女性，平均年龄69±5岁）和30名年龄匹配的对照者（15例男性，15例女性，平均年龄68±6岁）进行了评估。两组的人口统计学参数（年龄、性别、体重指数）相似。NTG患者的血浆CRP水平显著高于对照者（中位数[范围]，3.20[0.17 - 8.4]mg/dL，而对照者为0.5[0.1 - 3.2]mg/dL，P < 0.001）。与对照者相比，NTG患者的平均血浆CRP水平显著升高（分别为3.21±0.6mg/dL和0.85±0.17mg/dL，P < 0.01）。
我们的研究结果表明，较高的CRP水平可能与NTG有关。这种青光眼的病因可能涉及血管炎症过程。
