Stefan C, Nenciu A, Melinte Diana, Malcea Cristina, Nae Irina, Afanasiuc Olga
Sectia clinică Oftalmologie, Spitalul Clinic de Urgenţă Militar Central.
Oftalmologia. 2006;50(4):82-5.
To observe the possible implications of the C reactive protein in pathogenesis of the glaucoma.
A clinical observational prospective study on 2 groups: group A 14 glaucomatous patients and group B--control (12 normal subjects) without history of ocular pathology or general pathology known to be associated with high plasma levels of CRP. The groups were homogeneous about the age and sex distribution. CRP levels were evaluated by tests with high specificity.
The plasma CRP level reveals important differences (p < 0,0001) on the two groups: 3,87 +/- 0,8 mg/dl in the group A and 0,68 +/- 0,13 mg/dl in the control group.
Glaucoma is associated with high plasma levels of CRP. In the complex pathogenesis of glaucoma, in which the vascular factor has his well known place, the inflammatory vascular modifications may represent an important component.
观察C反应蛋白在青光眼发病机制中的可能影响。
对两组进行临床前瞻性观察研究：A组为14例青光眼患者，B组为对照组（12名正常受试者），这些受试者无已知与血浆CRP高水平相关的眼部或全身病史。两组在年龄和性别分布上具有同质性。通过高特异性检测评估CRP水平。
两组血浆CRP水平存在显著差异（p < 0.0001）：A组为3.87±0.8mg/dl，对照组为0.68±0.13mg/dl。
青光眼与血浆CRP高水平相关。在青光眼复杂的发病机制中，血管因素已被熟知，炎症性血管改变可能是一个重要组成部分。
