Manzoni Marla S J, Rossi Elizeu A, Carlos Iracilda Z, Vendramini Regina C, Duarte Ana C G O, Dâmaso Ana R
Departamento de Educação Física e Motricidade Humana, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Paulo, Brazil.
Nutrition. 2005 Oct;21(10):1018-24. doi: 10.1016/j.nut.2005.02.007.
This study investigated the effects of soy product fermented by Enterococcus faecium and Lactobacillus jugurti supplemented with isoflavones on adipose tissue, blood lipid, and glucose levels on juvenile rats.
Rats were fed a cholesterol-enriched diet for 3 wk as a preliminary treatment to create hypercholesterolemia. They were then fed a chow diet (HC), a chow diet plus fermented soy product supplemented with isoflavones (HCFI), a chow diet plus placebo (HCP), or a chow diet plus placebo supplemented with isoflavones (HCPI), respectively, for an additional 3 wk.
The beneficial effects of fermented soy product supplemented with isoflavones on epididymal (EPI) and retroperitoneal (RET) fat pads was likely due to isoflavones because adipocyte circumference (micrometers) in the HC group was significantly larger (EPI: 105.66 +/- 13.36; RET: 134.95 +/- 25.40) than that in the HCFI group (EPI: 93.17 +/- 12.80; RET: 108.62 +/- 15.50) and HCPI group (EPI: 93.06 +/- 15.10; RET: 112.34 +/- 18.21). The probiotic micro-organism accentuated the antilipogenic effect of isoflavones on RET (HCFI: 108.62 +/- 15.50 micrometers versus HCPI: 112.34 +/- 18.21 micrometers). Moreover, the fermented product increased glucose concentration similar to that in the chow group but did not change blood lipids.
This product may offer new approaches to obesity prevention.
本研究调查了添加异黄酮的粪肠球菌和约氏乳杆菌发酵豆制品对幼鼠脂肪组织、血脂和血糖水平的影响。
大鼠先接受为期3周的高胆固醇饮食作为初步处理以诱发高胆固醇血症。然后分别给予普通饲料（HC）、添加异黄酮的普通饲料加发酵豆制品（HCFI）、普通饲料加安慰剂（HCP）或普通饲料加添加异黄酮的安慰剂（HCPI），持续3周。
添加异黄酮的发酵豆制品对附睾（EPI）和腹膜后（RET）脂肪垫的有益作用可能归因于异黄酮，因为HC组的脂肪细胞周长（微米）显著大于HCFI组（EPI：105.66±13.36；RET：134.95±25.40）和HCPI组（EPI：93.06±15.10；RET：112.34±18.21）（EPI：93.17±12.80；RET：108.62±15.50）。益生菌微生物增强了异黄酮对RET的抗脂肪生成作用（HCFI：108.62±15.50微米对HCPI：112.34±18.21微米）。此外，发酵产品使葡萄糖浓度升高至与普通饲料组相似，但未改变血脂。
该产品可能为预防肥胖提供新方法。
