Maxwell Patrick H
Hammersmith Campus, Imperial College, London W12 0NN, UK.
Exp Physiol. 2005 Nov;90(6):791-7. doi: 10.1113/expphysiol.2005.030924. Epub 2005 Sep 12.
Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator that coordinates changes in gene transcription. HIF operates in all mammalian cell types and is ancient in evolutionary terms, being conserved in C. elegans and D. melanogaster. This review summarizes recent insights into the molecular events that link reduced oxygenation to HIF activation and emerging insights into the extensive role of HIF in a broad range of physiological processes.
缺氧诱导因子（HIF）是一种转录复合体，可对氧气变化作出反应，为细胞提供一种协调基因转录变化的主要调节因子。HIF在所有哺乳动物细胞类型中均发挥作用，从进化角度来看其存在已久，在秀丽隐杆线虫和黑腹果蝇中都保守存在。本综述总结了近期关于将氧合作用降低与HIF激活联系起来的分子事件的见解，以及关于HIF在广泛生理过程中的广泛作用的新见解。
