Langleben Daniel D, Loughead James W, Bilker Warren B, Ruparel Kosha, Childress Anna Rose, Busch Samantha I, Gur Ruben C
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Hum Brain Mapp. 2005 Dec;26(4):262-72. doi: 10.1002/hbm.20191.
Deception is a clinically important behavior with poorly understood neurobiological correlates. Published functional MRI (fMRI) data on the brain activity during deception indicates that, on a multisubject group level, lie is distinguished from truth by increased prefrontal and parietal activity. These findings are theoretically important; however, their applied value will be determined by the accuracy of the discrimination between single deceptive and truthful responses in individual subjects. This study presents the first quantitative estimate of the accuracy of fMRI in conjunction with a formal forced-choice paradigm in detecting deception in individual subjects. We used a paradigm balancing the salience of the target cues to elicit deceptive and truthful responses and determined the accuracy of this model in the classification of single lie and truth events. The relative salience of the task cues affected the net activation associated with lie in the superior medial and inferolateral prefrontal cortices. Lie was discriminated from truth on a single-event level with an accuracy of 78%, while the predictive ability expressed as the area under the curve (AUC) of the receiver operator characteristic curve (ROC) was 85%. Our findings confirm that fMRI, in conjunction with a carefully controlled query procedure, could be used to detect deception in individual subjects. Salience of the task cues is a potential confounding factor in the fMRI pattern attributed to deception in forced choice deception paradigms.
欺骗是一种临床重要行为，其神经生物学关联尚未得到充分理解。已发表的关于欺骗过程中大脑活动的功能磁共振成像（fMRI）数据表明，在多受试者群体水平上，说谎与说实话的区别在于前额叶和顶叶活动增加。这些发现具有重要的理论意义；然而，它们的应用价值将取决于个体受试者中单一欺骗性和真实反应之间区分的准确性。本研究首次结合正式的强制选择范式，对fMRI检测个体受试者欺骗行为的准确性进行了定量评估。我们使用了一种平衡目标线索显著性的范式来引发欺骗性和真实反应，并确定了该模型在单个说谎和真实事件分类中的准确性。任务线索的相对显著性影响了与前额叶上内侧和下外侧皮质说谎相关的净激活。在单事件水平上，说谎与说实话的区分准确率为78%，而以接受者操作特征曲线（ROC）的曲线下面积（AUC）表示的预测能力为85%。我们的研究结果证实，fMRI结合精心控制的询问程序，可用于检测个体受试者的欺骗行为。在强制选择欺骗范式中，任务线索的显著性是fMRI模式中归因于欺骗的一个潜在混杂因素。
