Embery G, Rölla G, Stanbury J B
Scand J Dent Res. 1979 Aug;87(4):318-24. doi: 10.1111/j.1600-0722.1979.tb00688.x.
Selected acidic glycosaminoglycans (GAG) have been used as a model series to study some binding properties of hydroxyapatite. The order of binding was heparin, heparin sulfate, dermatan sulfage/chondroitin-4-sulfate/chondroitin-6-sulfate (all similar) and hyaluronic acid, indicating that the negative charge on the molecules is a major determinant in the binding process. Both calcium and saliva pretreatment led to an increase in uptake of selected GAG whereas fluoride even at 1 and 3 parts/106 levels led to a graded reduction in uptake. The clinical significance of these findings may be related to the presence of certain GAG in the dental integuments and to the interaction of a chemically defined group of compounds at a specific solid surface. Such findings may also have an application in studies on endogenous mineralization. The results are in accord with the generally held view that polyanions may interact electrostatically with calcium sites present in the crystal lattice of the hydroxyapatite.
已选用一些酸性糖胺聚糖（GAG）作为模型系列，以研究羟基磷灰石的某些结合特性。结合顺序为肝素、硫酸肝素、硫酸皮肤素/硫酸软骨素-4/硫酸软骨素-6（均相似）和透明质酸，这表明分子上的负电荷是结合过程中的主要决定因素。钙和唾液预处理均导致所选GAG摄取增加，而氟即使在1和3 ppm水平也导致摄取逐渐减少。这些发现的临床意义可能与牙体被膜中某些GAG的存在以及特定固体表面上一组化学定义的化合物的相互作用有关。这些发现也可能在内源性矿化研究中具有应用价值。结果与普遍观点一致，即聚阴离子可能与羟基磷灰石晶格中存在的钙位点发生静电相互作用。
