Kirihara Kenji, Araki Tsuyoshi, Kasai Kiyoto, Maeda Keiko, Hata Akinobu, Uetsuki Miki, Yamasue Hidenori, Rogers Mark A, Kato Nobumasa, Iwanami Akira
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan.
Schizophr Res. 2005 Dec 15;80(2-3):197-201. doi: 10.1016/j.schres.2005.08.003. Epub 2005 Sep 19.
We have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia.
我们之前曾报道，在一组慢性精神分裂症患者样本中，通过阳性思维障碍综合指数评估发现，听觉P300事件相关电位的波幅降低与阳性思维障碍的严重程度之间存在关联。在此，我们在一个新的更大的由55名患者组成的样本中，使用不同的测量方法——思维障碍指数（TDI），重复了这些发现。听觉P300波幅与TDI得分呈显著负相关。这种相关性在左侧颞叶区域比右侧颞叶区域相对更明显。这些结果进一步表明，信息处理的电生理异常可能是精神分裂症阳性思维障碍的基础。
