Wheeler D, Keiser P, Rigamonti D, Keay S
Department of Medicine, University of Maryland Medical Center, Baltimore.
Clin Infect Dis. 1992 Jul;15(1):22-7. doi: 10.1093/clinids/15.1.22.
Although the traditional management of spinal epidural abscesses includes antibiotic therapy and surgical drainage, numerous reports have appeared in the literature that describe a nonsurgical approach. We report the successful nonsurgical management of a case of an extensive spinal epidural abscess in which the patient was closely monitored by serial studies with magnetic resonance imaging. Review of the literature from 1970 to 1990 revealed 37 cases that describe conservative management of spinal epidural abscesses. Despite successful conservative management reported for some cases, sudden neurological deterioration of patients receiving appropriate antibiotic therapy has also occurred. A true index of the success of nonsurgical therapy is difficult to discern since cases may have been selectively reported and unsuccessful attempts at conservative management may have never been reported once a laminectomy was performed. A prospective investigation that includes clearly defined indications for conservative management vs. surgical intervention and that can be studied with an intention-to-treat analysis is needed.
虽然传统上对脊柱硬膜外脓肿的治疗包括抗生素治疗和手术引流,但文献中已出现大量描述非手术治疗方法的报告。我们报告了1例广泛脊柱硬膜外脓肿成功接受非手术治疗的病例,该患者通过磁共振成像系列研究进行密切监测。回顾1970年至1990年的文献发现了37例描述脊柱硬膜外脓肿保守治疗的病例。尽管有报道称部分病例保守治疗成功,但接受适当抗生素治疗的患者也出现过突然的神经功能恶化。由于病例可能是经过选择性报告的,而且一旦进行了椎板切除术,保守治疗的失败尝试可能从未被报告过,因此很难辨别非手术治疗成功的真实指标。需要进行一项前瞻性研究,明确保守治疗与手术干预的适应症,并能进行意向性分析。