Segal G H, Mesa M V, Fishleder A J, Stoler M H, Weick J K, Lichtin A E, Tubbs R R
Department of Pathology, Cleveland Clinic Foundation, Ohio.
Cancer. 1992 Jul 15;70(2):547-53. doi: 10.1002/1097-0142(19920715)70:2<547::aid-cncr2820700227>3.0.co;2-z.
Langerhans cell precursors are considered to be identical to their mature counterparts except for the lack of Birbeck granules. Proliferations composed of such histiocytes appear to be uncommon.
Standard immunophenotypic, molecular genetic, and DNA content studies were used to characterize various hematopoietic disorders, including a proliferation of precursor Langerhans cells, which arose sequentially in a patient.
The patient studied initially had a low-grade, B-cell, non-Hodgkin lymphoma and subsequently had an unusual histiocytic proliferation (precursor Langerhans cell histiocytosis) in cutaneous and lymph node sites. The patient eventually died of acute myelogenous leukemia (FAB, M5).
A larger series is required to determine the significance of the precursor Langerhans cell phenotype, particularly with respect to the development of acute myelogenous leukemia.
朗格汉斯细胞前体细胞被认为除了缺乏伯贝克颗粒外，与它们的成熟对应细胞相同。由这类组织细胞组成的增殖似乎并不常见。
采用标准免疫表型、分子遗传学和DNA含量研究来表征各种造血系统疾病，包括一名患者先后出现的前体朗格汉斯细胞增殖。
所研究的患者最初患有低度B细胞非霍奇金淋巴瘤，随后在皮肤和淋巴结部位出现了一种不寻常的组织细胞增殖（前体朗格汉斯细胞组织细胞增生症）。该患者最终死于急性髓系白血病（FAB，M5）。
需要更大规模的系列研究来确定前体朗格汉斯细胞表型的意义，特别是关于急性髓系白血病的发生发展。
